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Efficacy of Gemcitabine-based Chemotherapy in Clear Cell Sarcoma of Soft Tissue.

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Date
2020-12
ICR Author
Huang, Paul
Messiou, Christina
Author
Cojocaru, E
Thway, K
Fisher, C
Messiou, C
Zaidi, S
Miah, AB
Benson, C
Gennatas, S
Huang, P
Jones, RL
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Type
Journal Article
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Abstract
Background/aim Clear cell sarcoma (CCS) is an aggressive sarcoma subtype, resistant to conventional anthracycline-based chemotherapy and radiation. The diagnosis is often challenging due to similarities with malignant melanoma.Patients and methods We aimed to analyse the activity of gemcitabine-based chemotherapy in a cohort of patients with CCS treated at the Royal Marsden Hospital.Results Five patients with metastatic CCS received gemcitabine as first- or second-line systemic therapy. The median time-to-progression was 10 weeks. The median number of cycles of gemcitabine-based therapy was 3 (range=2-7 cycles). Median overall survival in our cohort was 66 months from the initial diagnosis but in the metastatic setting, the overall survival was reduced to 28 months.Conclusion Gemcitabine-based therapy has modest activity in CCS. There remains a significant unmet medical need for novel, effective therapies for this disease.
URI
https://repository.icr.ac.uk/handle/internal/4320
DOI
https://doi.org/10.21873/anticanres.14725
Collections
  • Molecular Pathology
Subject
Humans
Sarcoma, Clear Cell
Soft Tissue Neoplasms
Deoxycytidine
Antimetabolites, Antineoplastic
Adult
Middle Aged
Female
Male
Research team
Molecular and Systems Oncology
Language
eng
Date accepted
2020-11-08
License start date
2020-12
Citation
Anticancer research, 2020, 40 (12), pp. 7003 - 7007

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