Browsing by author "Garcia-Closas, Montserrat"
Now showing items 1-20 of 21
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Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Zhang, YD; Hurson, AN; Zhang, H; Choudhury, PP; Easton, DF; et al. (NATURE PORTFOLIO, 2020-07-03)Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of ... -
Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer.
Abubakar, M; Figueroa, J; Ali, HR; Blows, F; Lissowska, J; et al. (NATURE PUBLISHING GROUP, 2019-09-01)Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to prospectively determine those for whom additional cytotoxic therapy ... -
Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification.
Pal Choudhury, P; Wilcox, AN; Brook, MN; Zhang, Y; Ahearn, T; et al. (OXFORD UNIV PRESS INC, 2020-03-01)BACKGROUND: External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development ... -
Comparative validation of the BOADICEA and Tyrer-Cuzick breast cancer risk models incorporating classical risk factors and polygenic risk in a population-based prospective cohort of women of European ancestry.
Pal Choudhury, P; Brook, MN; Hurson, AN; Lee, A; Mulder, CV; et al. (BMC, 2021-02-15)BACKGROUND: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) and the Tyrer-Cuzick breast cancer risk prediction models are commonly used in clinical practice and have recently ... -
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Fehringer, G; Kraft, P; Pharoah, PD; Eeles, RA; Chatterjee, N; et al. (AMER ASSOC CANCER RESEARCH, 2016-09-01)Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, ... -
Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1.
Koutros, S; Baris, D; Fischer, A; Tang, W; Garcia-Closas, M; et al. (WILEY-BLACKWELL, 2013-12-15)Genome-wide association studies (GWAS) identified associations between markers within the solute carrier family 14 (urea transporter), member 1 (SLC14A1) gene and risk of bladder cancer. SLC14A1 defines the Kidd blood ... -
DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer.
Koka, H; Bodelon, C; Horvath, S; Lee, PMY; Wang, D; et al. (BMC, 2023-03-30)BACKGROUND: Few studies have examined epigenetic age acceleration (AA), the difference between DNA methylation (DNAm) predicted age and chronological age, in relation to somatic genomic features in paired cancer and normal ... -
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation.
Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; et al. (WILEY, 2018-08-15)Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ... -
Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.
Barrdahl, M; Rudolph, A; Hopper, JL; Southey, MC; Broeks, A; et al. (WILEY, 2017-11-01)Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene-environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified ... -
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
Guo, Y; Warren Andersen, S; Shu, X-O; Michailidou, K; Bolla, MK; et al. (PUBLIC LIBRARY SCIENCE, 2016-08-23)BACKGROUND: Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is ... -
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
Kar, SP; Beesley, J; Amin Al Olama, A; Michailidou, K; Tyrer, J; et al. (AMER ASSOC CANCER RESEARCH, 2016-09-01)UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining ... -
High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium.
Abubakar, M; Howat, WJ; Daley, F; Zabaglo, L; McDuffus, L-A; et al. (WILEY, 2016-07-01)Automated methods are needed to facilitate high-throughput and reproducible scoring of Ki67 and other markers in breast cancer tissue microarrays (TMAs) in large-scale studies. To address this need, we developed an automated ... -
Increase in power by obtaining 10 or more controls per case when type-1 error is small in large-scale association studies.
Katki, HA; Berndt, SI; Machiela, MJ; Stewart, DR; Garcia-Closas, M; et al. (BMC, 2023-06-29)BACKGROUND: The rule of thumb that there is little gain in statistical power by obtaining more than 4 controls per case, is based on type-1 error α = 0.05. However, association studies that evaluate thousands or millions ... -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Michailidou, K; Hall, P; Gonzalez-Neira, A; Ghoussaini, M; Dennis, J; et al. (NATURE PUBLISHING GROUP, 2013-04-01)Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We ... -
Mosquito control exposures and breast cancer risk: analysis of 1071 cases and 2096 controls from the Ghana Breast Health Study.
Olivos, N; Banta, JE; Spencer-Hwang, R; Ansong, D; Beane Freeman, LE; et al. (BMC, 2023-12-11)Epidemiologic data on insecticide exposures and breast cancer risk are inconclusive and mostly from high-income countries. Using data from 1071 invasive pathologically confirmed breast cancer cases and 2096 controls from ... -
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Southey, MC; Goldgar, DE; Winqvist, R; Pylkäs, K; Couch, F; et al. (BMJ PUBLISHING GROUP, 2016-12-01)BACKGROUND: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ... -
Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status.
Rotunno, M; Sun, X; Figueroa, J; Sherman, ME; Garcia-Closas, M; et al. (BMC, 2014-07-08)INTRODUCTION: Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor-positive breast tumors, but may increase risk for basal-like breast ... -
Potential utility of risk stratification for multicancer screening with liquid biopsy tests.
Kim, ES; Scharpf, RB; Garcia-Closas, M; Visvanathan, K; Velculescu, VE; et al. (NATURE PORTFOLIO, 2023-04-22)Our proof-of-concept study reveals the potential of risk stratification by the combined effects of age, polygenic risk scores (PRS), and non-genetic risk factors in increasing the risk-benefit balance of rapidly emerging ... -
Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups.
Abubakar, M; Orr, N; Daley, F; Coulson, P; Ali, HR; et al. (BIOMED CENTRAL LTD, 2016-10-18)BACKGROUND: The value of KI67 in breast cancer prognostication has been questioned due to concerns on the analytical validity of visual KI67 assessment and methodological limitations of published studies. Here, we investigate ... -
Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.
Brouckaert, O; Rudolph, A; Laenen, A; Keeman, R; Bolla, MK; et al. (BMC, 2017-12-01)BACKGROUND: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors ...