Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Dos Santos Silva, I
van der Luijt, RB
van der Schoot, CE
Le Marchand, L
van den Ouweland, AM
van Asperen, CJ
Van Den Berg, D
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Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
Version of record
Breast and Ovarian Cancer Susceptibility Collaboration
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
Australian Ovarian Cancer Study Group
GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Meta-Analysis as Topic
Genome-Wide Association Study
Complex Trait Genetics
Functional Genetic Epidemiology
Predisposition & Translation Genetics
Molecular & Population Genetics
License start date
Nature genetics, 2013, 45 (4), pp. 353 - 361e2
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