Potential utility of risk stratification for multicancer screening with liquid biopsy tests.
Date
2023-04-22ICR Author
Author
Kim, ES
Scharpf, RB
Garcia-Closas, M
Visvanathan, K
Velculescu, VE
Chatterjee, N
Type
Journal Article
Metadata
Show full item recordAbstract
Our proof-of-concept study reveals the potential of risk stratification by the combined effects of age, polygenic risk scores (PRS), and non-genetic risk factors in increasing the risk-benefit balance of rapidly emerging non-invasive multicancer early detection (MCED) liquid biopsy tests. We develop and validate sex-specific pan-cancer risk scores (PCRSs), defined by the combination of body mass index, smoking, family history of cancers, and cancer-specific polygenic risk scores (PRSs), to predict the absolute risk of developing at least one of the many common cancer types. We demonstrate the added value of PRSs in improving the predictive performance of the risk factors only model and project the positive and negative predictive values for two promising multicancer screening tests across risk strata defined by age and PCRS.
Collections
Subject
Science & Technology
Life Sciences & Biomedicine
Oncology
CANCER-RISK
UK BIOBANK
MUTATIONS
UPDATE
DNA
Research team
Integrative Cancer Epidem
Language
eng
Date accepted
2023-03-30
License start date
2023-04-22
Citation
npj Precision Oncology, 2023, 7 (1), pp. 39 -
Publisher
NATURE PORTFOLIO