Browsing by author "Meier, Pascal"
Now showing items 21-31 of 31
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Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis.
Tsapras, P; Petridi, S; Chan, S; Geborys, M; Jacomin, A-C; et al. (CELL PRESS, 2022-01-25)Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical ... -
Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense.
Morris, O; Liu, X; Domingues, C; Runchel, C; Chai, A; et al. (CELL PRESS, 2016-09-14)Pattern recognition receptors are activated following infection and trigger transcriptional programs important for host defense. Tight regulation of NF-κB activation is critical to avoid detrimental and misbalanced responses. ... -
SUMO-mediated regulation of NLRP3 modulates inflammasome activity.
Barry, R; John, SW; Liccardi, G; Tenev, T; Jaco, I; et al. (NATURE PUBLISHING GROUP, 2018-08-01)The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. How the NLRP3 inflammasome is ... -
The anticonvulsive Phenhydan® suppresses extrinsic cell death.
Moerke, C; Jaco, I; Dewitz, C; Müller, T; Jacobsen, AV; et al. (NATURE PUBLISHING GROUP, 2019-09-01)Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology of clinical conditions including ischemia-reperfusion injury, myocardial infarction, sepsis, and multiple sclerosis. ... -
The Diversification of Cell Death and Immunity: Memento Mori.
Legrand, AJ; Konstantinou, M; Goode, EF; Meier, P (CELL PRESS, 2019-10-01)Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell ... -
The NMDA receptor regulates competition of epithelial cells in the Drosophila wing.
Banreti, AR; Meier, P (NATURE PUBLISHING GROUP, 2020-05-06)Cell competition is an emerging principle that eliminates suboptimal or potentially dangerous cells. For 'unfit' cells to be detected, their competitive status needs to be compared to the collective fitness of cells within ... -
The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.
Neyen, C; Runchel, C; Schüpfer, F; Meier, P; Lemaitre, B (NATURE PUBLISHING GROUP, 2016-08-22)The innate immune system needs to distinguish between harmful and innocuous stimuli to adapt its activation to the level of threat. How Drosophila mounts differential immune responses to dead and live Gram-negative bacteria ... -
The regulatory isoform rPGRP-LC resolves immune activation through receptor clearance via ESCRT-mediated trafficking
Meier, P; neyen, C; runchel, C; schupfer, F; lemaitre, B (Nature Publishing Group, 2016-10-01) -
The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.
Orme, MH; Liccardi, G; Moderau, N; Feltham, R; Wicky-John, S; et al. (NATURE PUBLISHING GROUP, 2016-03-10)Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under non-apoptotic conditions and process ... -
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.
Annibaldi, A; Wicky John, S; Vanden Berghe, T; Swatek, KN; Ruan, J; et al. (CELL PRESS, 2018-02-15)Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains ... -
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Garcia, LR; Tenev, T; Newman, R; Haich, RO; Liccardi, G; et al. (NATURE PORTFOLIO, 2021-06-07)Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which ...