The Diversification of Cell Death and Immunity: Memento Mori.
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Date
2019-10-01Author
Legrand, AJ
Konstantinou, M
Goode, EF
Meier, P
Type
Journal Article
Metadata
Show full item recordAbstract
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and multiplied to cover the complexity of the foes the immune system faces. In this review, we discuss the different types of cell death, the underlying signaling events, and their unequal ability to trigger an immune response. We also comment on how to use our knowledge of cell death signaling to improve the efficacy of cancer treatment. We argue that cell death is integral to the immune response and acts as a beacon, a second messenger, that guides both immune system and tissue micro-environment to ensure tissue repair and homeostasis. Memento mori-"remember you must die"-as failure to do so opens the way to chronic infection and cancer.
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Subject
Lymphocytes, Tumor-Infiltrating
Animals
Humans
Neoplasms
Antineoplastic Agents
Immunotherapy
Signal Transduction
Apoptosis
Tumor Escape
Oncolytic Virotherapy
Apoptosis Regulatory Proteins
Cellular Microenvironment
Pyroptosis
Necroptosis
Ferroptosis
Research team
Cell Death and Immunity
Language
eng
Date accepted
2019-09-06
License start date
2019-10-02
Citation
Molecular cell, 2019, 76 (2), pp. 232 - 242
Publisher
CELL PRESS