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dc.contributor.authorLegrand, AJ
dc.contributor.authorKonstantinou, M
dc.contributor.authorGoode, EF
dc.contributor.authorMeier, P
dc.date.accessioned2019-10-23T15:14:14Z
dc.date.issued2019-10-02
dc.identifier.citationMolecular cell, 2019, 76 (2), pp. 232 - 242
dc.identifier.issn1097-2765
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3394
dc.identifier.eissn1097-4164
dc.identifier.doi10.1016/j.molcel.2019.09.006
dc.description.abstractWhy do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and multiplied to cover the complexity of the foes the immune system faces. In this review, we discuss the different types of cell death, the underlying signaling events, and their unequal ability to trigger an immune response. We also comment on how to use our knowledge of cell death signaling to improve the efficacy of cancer treatment. We argue that cell death is integral to the immune response and acts as a beacon, a second messenger, that guides both immune system and tissue micro-environment to ensure tissue repair and homeostasis. Memento mori-"remember you must die"-as failure to do so opens the way to chronic infection and cancer.
dc.formatPrint-Electronic
dc.format.extent232 - 242
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectLymphocytes, Tumor-Infiltrating
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectAntineoplastic Agents
dc.subjectImmunotherapy
dc.subjectSignal Transduction
dc.subjectApoptosis
dc.subjectTumor Escape
dc.subjectOncolytic Virotherapy
dc.subjectApoptosis Regulatory Proteins
dc.subjectCellular Microenvironment
dc.subjectPyroptosis
dc.subjectNecroptosis
dc.subjectFerroptosis
dc.titleThe Diversification of Cell Death and Immunity: Memento Mori.
dc.typeJournal Article
dcterms.dateAccepted2019-09-06
rioxxterms.versionofrecord10.1016/j.molcel.2019.09.006
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2019-10-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMolecular cell
pubs.issue2
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Cell Death and Immunity
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/17/18 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Cell Death and Immunity
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/17/18 Starting Cohort
pubs.publication-statusPublished
pubs.volume76
pubs.embargo.termsNo embargo
icr.researchteamCell Death and Immunityen_US
dc.contributor.icrauthorKonstantinou, Mariaen
dc.contributor.icrauthorGoode, Emilyen
dc.contributor.icrauthorMeier, Pascalen
dc.contributor.icrauthorLegrand, Arnauden


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