Now showing items 1708-1727 of 4441

    • Genomics of lethal prostate cancer at diagnosis and castration resistance. 

      Mateo, J; Seed, G; Bertan, C; Rescigno, P; Dolling, D; Figueiredo, I; Miranda, S; Nava Rodrigues, D; Gurel, B; Clarke, M; Atkin, M; Chandler, R; Messina, C; Sumanasuriya, S; Bianchini, D; Barrero, M; Petermolo, A; Zafeiriou, Z; Fontes, M; Perez-Lopez, R; Tunariu, N; Fulton, B; Jones, R; McGovern, U; Ralph, C; Varughese, M; Parikh, O; Jain, S; Elliott, T; Sandhu, S; Porta, N; Hall, E; Yuan, W; Carreira, S; de Bono, JS (2020-04)
      The genomics of primary prostate cancer differ from those of metastatic castration-resistant prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer biopsies from patients who developed mCRPC, ...
    • Genomics, bio specimens, and other biological data: Current status and future directions. 

      Rosenstein, BS; Rao, A; Moran, JM; Spratt, DE; Mendonca, MS; Al-Lazikani, B; Mayo, CS; Speers, C (2018-10)
    • Genotoxicity of human breast milk from different countries 

      Martin, FL; Cole, KJ; Weaver, G; Hong, GS; Lam, BC; Balaram, P; Grover, PL; Phillips, DH (OXFORD UNIV PRESS, 2001-09)
      Dietary and/or environmental factors appear to play a key role in the international variations that exist in breast cancer incidence. The genotoxicity of breast milk extracts is being examined as a possible indicator of ...
    • Genotoxins and the initiation of sporadic breast cancer 

      Martin, FL (2001-03)
      Breast cancer is the most frequently diagnosed female malignancy world-wide. The aetiology of the majority of cases remains obscure and the only genotoxin as yet known to initiate breast cancer is ionizing radiation, High ...
    • Geometric and dosimetric evaluation of the differences between rigid and deformable registration to assess interfraction motion during pelvic radiotherapy. 

      White, I; McQuaid, D; McNair, H; Dunlop, A; Court, S; Hopkins, N; Thomas, K; Dearnaley, D; Bhide, S; Lalondrelle, S (2019-01)
      <h4>Background and purpose</h4>Appropriate internal margins are essential to avoid a geographical miss in intensity-modulated radiation therapy (IMRT) for endometrial cancer (EC). This study evaluated interfraction target ...
    • Geometric and dosimetric evaluations of atlas-based segmentation methods of MR images in the head and neck region. 

      Kieselmann, JP; Kamerling, CP; Burgos, N; Menten, MJ; Fuller, CD; Nill, S; Cardoso, MJ; Oelfke, U (2018-07-11)
      Owing to its excellent soft-tissue contrast, magnetic resonance (MR) imaging has found an increased application in radiation therapy (RT). By harnessing these properties for treatment planning, automated segmentation methods ...
    • Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia. 

      Speedy, HE; Kinnersley, B; Chubb, D; Broderick, P; Law, PJ; Litchfield, K; Jayne, S; Dyer, MJS; Dearden, C; Follows, GA; Catovsky, D; Houlston, RS (2016-11)
      Chronic lymphocytic leukemia (CLL) can be familial; however, thus far no rare germ line disruptive alleles for CLL have been identified. We performed whole-exome sequencing of 66 CLL families, identifying 4 families where ...
    • Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression, and drug response. 

      Zhang, P; Kitchen-Smith, I; Xiong, L; Stracquadanio, G; Brown, K; Richter, PH; Wallace, MD; Bond, E; Sahgal, N; Moore, S; Nornes, S; De Val, S; Surakhy, M; Sims, D; Wang, X; Bell, DA; Zeron-Medina, J; Jiang, Y; Ryan, AJ; Selfe, JL; Shipley, J; Kar, S; Pharoah, PDP; Loveday, C; Jansen, R; Grochola, LF; Palles, C; Protheroe, A; Millar, V; Ebner, DV; Pagadala, M; Blagden, SP; Maughan, TS; Domingo, E; Tomlinson, I; Turnbull, C; Carter, H; Bond, GL (2021-02-08)
      Insights into oncogenesis derived from cancer susceptibility loci (single nucleotide polymorphisms, SNP) hold the potential to facilitate better cancer management and treatment through precision oncology. However, therapeutic ...
    • Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study. 

      Copson, ER; Maishman, TC; Tapper, WJ; Cutress, RI; Greville-Heygate, S; Altman, DG; Eccles, B; Gerty, S; Durcan, LT; Jones, L; Evans, DG; Thompson, AM; Pharoah, P; Easton, DF; Dunning, AM; Hanby, A; Lakhani, S; Eeles, R; Gilbert, FJ; Hamed, H; Hodgson, S; Simmonds, P; Stanton, L; Eccles, DM (2018-02)
      <h4>Background</h4>Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the ...
    • Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel. 

      Leongamornlert, DA; Saunders, EJ; Wakerell, S; Whitmore, I; Dadaev, T; Cieza-Borrella, C; Benafif, S; Brook, MN; Donovan, JL; Hamdy, FC; Neal, DE; Muir, K; Govindasami, K; Conti, DV; Kote-Jarai, Z; Eeles, RA (2019-09)
      <h4>Background</h4>Rare germline mutations in DNA repair genes are associated with prostate cancer (PCa) predisposition and prognosis.<h4>Objective</h4>To quantify the frequency of germline DNA repair gene mutations in UK ...
    • Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT. 

      Ahmed, M; Goh, C; Saunders, E; Cieza-Borrella, C; PRACTICAL consortium; Kote-Jarai, Z; Schumacher, FR; Eeles, R (2020-06)
      <h4>Background</h4>The development of prostate cancer can be influenced by genetic and environmental factors. Numerous germline SNPs influence prostate cancer susceptibility. The functional pathways in which these SNPs ...
    • Germline mutations in BRCA1 and BRCA2 in breast-ovarian families from a breast cancer risk evaluation clinic 

      Stratton, M (2001-04)
      Germline mutations in BRCA1 and BRCA2 in breast-ovarian families from a breast cancer risk evaluation clinic. Purpose: Data from the Breast Cancer Linkage Consortium suggest that the proportion of familial breast and ovarian ...
    • Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour. 

      Hanks, S; Perdeaux, ER; Seal, S; Ruark, E; Mahamdallie, SS; Murray, A; Ramsay, E; Del Vecchio Duarte, S; Zachariou, A; de Souza, B; Warren-Perry, M; Elliott, A; Davidson, A; Price, H; Stiller, C; Pritchard-Jones, K; Rahman, N (2014-08-07)
      Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population ...
    • Germline sequencing DNA repair genes in 5,545 men with aggressive and non-aggressive prostate cancer. 

      Darst, BF; Dadaev, T; Saunders, E; Sheng, X; Wan, P; Pooler, L; Xia, LY; Chanock, S; Berndt, SI; Gapstur, SM; Stevens, V; Albanes, D; Weinstein, SJ; Gnanapragasam, V; Giles, GG; Nguyen-Dumont, T; Milne, RL; Pomerantz, M; Schmidt, JA; Mucci, L; Catalona, WJ; Hetrick, KN; Doheny, KF; MacInnis, RJ; Southey, MC; Eeles, RA; Wiklund, F; Kote-Jarai, Z; Conti, DV; Haiman, CA (2020-08-27)
      <h4>Background</h4>There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline ...
    • Germline variants at SOHLH2 influence multiple myeloma risk. 

      Duran-Lozano, L; Thorleifsson, G; Lopez de Lapuente Portilla, A; Niroula, A; Went, M; Thodberg, M; Pertesi, M; Ajore, R; Cafaro, C; Olason, PI; Stefansdottir, L; Bragi Walters, G; Halldorsson, GH; Turesson, I; Kaiser, MF; Weinhold, N; Abildgaard, N; Andersen, NF; Mellqvist, U-H; Waage, A; Juul-Vangsted, A; Thorsteinsdottir, U; Hansson, M; Houlston, R; Rafnar, T; Stefansson, K; Nilsson, B (2021-04-19)
      Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a ...
    • Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases. 

      FitzGerald, LM; Zhao, S; Leonardson, A; Geybels, MS; Kolb, S; Lin, DW; Wright, JL; Eeles, R; Kote-Jarai, Z; Govindasami, K; Giles, GG; Southey, MC; Schleutker, J; Tammela, TL; Sipeky, C; Penney, KL; Stampfer, MJ; Gronberg, H; Wiklund, F; Stattin, P; Hugosson, J; Karyadi, DM; Ostrander, EA; Feng, Z; Stanford, JL (2018-06)
      BACKGROUND:Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further ...
    • Germline variation at 8q24 and prostate cancer risk in men of European ancestry. 

      Matejcic, M; Saunders, EJ; Dadaev, T; Brook, MN; Wang, K; Sheng, X; Olama, AAA; Schumacher, FR; Ingles, SA; Govindasami, K; Benlloch, S; Berndt, SI; Albanes, D; Koutros, S; Muir, K; Stevens, VL; Gapstur, SM; Tangen, CM; Batra, J; Clements, J; Gronberg, H; Pashayan, N; Schleutker, J; Wolk, A; West, C; Mucci, L; Kraft, P; Cancel-Tassin, G; Sorensen, KD; Maehle, L; Grindedal, EM; Strom, SS; Neal, DE; Hamdy, FC; Donovan, JL; Travis, RC; Hamilton, RJ; Rosenstein, B; Lu, Y-J; Giles, GG; Kibel, AS; Vega, A; Bensen, JT; Kogevinas, M; Penney, KL; Park, JY; Stanford, JL; Cybulski, C; Nordestgaard, BG; Brenner, H; Maier, C; Kim, J; Teixeira, MR; Neuhausen, SL; De Ruyck, K; Razack, A; Newcomb, LF; Lessel, D; Kaneva, R; Usmani, N; Claessens, F; Townsend, PA; Gago-Dominguez, M; Roobol, MJ; Menegaux, F; Khaw, K-T; Cannon-Albright, LA; Pandha, H; Thibodeau, SN; Schaid, DJ; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Wiklund, F; Chanock, SJ; Easton, DF; Eeles, RA; Kote-Jarai, Z; Conti, DV; Haiman, CA (2018-11-05)
      Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
    • Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group. 

      Mandelker, D; Donoghue, M; Talukdar, S; Bandlamudi, C; Srinivasan, P; Vivek, M; Jezdic, S; Hanson, H; Snape, K; Kulkarni, A; Hawkes, L; Douillard, J-Y; Wallace, SE; Rial-Sebbag, E; Meric-Bersntam, F; George, A; Chubb, D; Loveday, C; Ladanyi, M; Berger, MF; Taylor, BS; Turnbull, C (2019-08)
      It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in cancer susceptibility genes identified on tumour-only sequencing, it is often unclear ...
    • The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. 

      Amirian, ES; Armstrong, GN; Zhou, R; Lau, CC; Claus, EB; Barnholtz-Sloan, JS; Il'yasova, D; Schildkraut, J; Ali-Osman, F; Sadetzki, S; Johansen, C; Houlston, RS; Jenkins, RB; Lachance, D; Olson, SH; Bernstein, JL; Merrell, RT; Wrensch, MR; Davis, FG; Lai, R; Shete, S; Amos, CI; Scheurer, ME; Aldape, K; Alafuzoff, I; Brännström, T; Broholm, H; Collins, P; Giannini, C; Rosenblum, M; Tihan, T; Melin, BS; Bondy, ML (2016-01)
      Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity ...
    • Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics. 

      Ostrom, QT; Egan, KM; Nabors, LB; Gerke, T; Thompson, RC; Olson, JJ; LaRocca, R; Chowdhary, S; Eckel-Passow, JE; Armstrong, G; Wiencke, JK; Bernstein, JL; Claus, EB; Il'yasova, D; Johansen, C; Lachance, DH; Lai, RK; Merrell, RT; Olson, SH; Sadetzki, S; Schildkraut, JM; Shete, S; Houlston, RS; Jenkins, RB; Wrensch, MR; Melin, B; Amos, CI; Huse, JT; Barnholtz-Sloan, JS; Bondy, ML (2020-02)
      Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have ...