Extrameningeal solitary fibrous tumors-surgery alone or surgery plus perioperative radiotherapy: A retrospective study from the global solitary fibrous tumor initiative in collaboration with the Sarcoma Patients EuroNet.
Date
2020-07-01ICR Author
Author
Haas, RL
Walraven, I
Lecointe-Artzner, E
van Houdt, WJ
Strauss, D
Schrage, Y
Hayes, AJ
Raut, CP
Fairweather, M
Baldini, EH
Gronchi, A
De Rosa, L
Griffin, AM
Ferguson, PC
Wunder, J
van de Sande, MAJ
Krol, ADG
Skoczylas, J
Sangalli, C
Stacchiotti, S
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: Solitary fibrous tumor (SFT) is a rare mesenchymal malignancy. Although surgery is potentially curative, the local relapse risk is high after marginal resections. Given the lack of prospective clinical trial data, the objective of the current study was to better define the role of perioperative radiotherapy (RT) in various SFT presentations by location. METHODS: This was retrospective study performed across 7 sarcoma centers. Clinical information was retrieved from all adult patients with extrameningeal, primary, localized SFT who were treated between 1990 and 2018 with surgery alone (S) compared with those who also received perioperative RT (S+RT). Differences in treatment characteristics between subgroups were tested using analysis of variance statistics and propensity score matching. Local control and overall survival rates were calculated from the start of treatment until progression or death from any cause. RESULTS: Of all 549 patients, 428 (78%) underwent S, and 121 (22%) underwent S+RT. The median follow-up was 52 months. After correction for mitotic count and surgical margins, S+RT was significantly associated with a lower risk of local progression (hazard ratio, 0.19: P = .029), an observation further confirmed by propensity score matching (P = .012); however, this association did not translate into an overall survival benefit. CONCLUSIONS: The results from this retrospective study investigating perioperative RT in patients with primary extrameningeal SFT suggest that combining RT with surgery in the management of this patient population is significantly associated with a reduced risk of local failures, especially in patients who have less favorable resection margins and in those who have tumors with a high mitotic count.
Collections
Subject
hemangiopericytoma
patient advocacy group
radiotherapy
solitary fibrous tumor
surgery
Analysis of Variance
Combined Modality Therapy
Disease Progression
Extremities
Female
Follow-Up Studies
Head and Neck Neoplasms
Humans
Male
Middle Aged
Mitotic Index
Progression-Free Survival
Propensity Score
Retroperitoneal Neoplasms
Retrospective Studies
Solitary Fibrous Tumor, Pleural
Solitary Fibrous Tumors
Survival Rate
Torso
Research team
Sarcoma&Melanoma Surgery
Language
eng
Date accepted
2020-03-30
License start date
2020-07-01
Citation
Cancer, 2020, 126 (13), pp. 3002 - 3012
Publisher
WILEY
Except where otherwise noted, this item's license is described
as
https://creativecommons.org/licenses/by-nc-nd/4.0/
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