Browsing ICR Divisions by author "Williams, Sophie"

Now showing items 1-3 of 3

    • Replication-induced DNA secondary structures drive fork uncoupling and breakage. 

      Williams, SL; Casas-Delucchi, CS; Raguseo, F; Guneri, D; Li, Y; et al. (WILEY, 2023-11-15)
      Sequences that form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play various physiological roles. However, they can also interfere with replication ...

    • The response of the Eukaryotic replisome to DNA quadruplex structures 

      Coster G; Williams, S; Coster, G (Institute of Cancer Research (University Of London), 2024-01-18)
      Sequences that can form DNA secondary structures, such as G-quadruplexes (G4s) and intercalated-Motifs (iMs), are abundant in the human genome and play a range of physiological roles. However, they can pose a challenge to ...

    • The mechanism of replication stalling and recovery within repetitive DNA. 

      Casas-Delucchi, CS; Daza-Martin, M; Williams, SL; Coster, G (NATURE PORTFOLIO, 2022-07-19)
      Accurate chromosomal DNA replication is essential to maintain genomic stability. Genetic evidence suggests that certain repetitive sequences impair replication, yet the underlying mechanism is poorly defined. Replication ...