Now showing items 1-2 of 2

    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. 

      Wan, PTC; Garnett, MJ; Roe, SM; Lee, S; Niculescu-Duvaz, D; Good, VM; Jones, CM; Marshall, CJ; Springer, CJ; Barford, D; Marais, R; Cancer Genome Project (2004-03)
      Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kinase domain. Here we show that of 22 B-RAF mutants analyzed, 18 have elevated kinase ...
    • Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. 

      da Fonseca, PCA; Kong, EH; Zhang, Z; Schreiber, A; Williams, MA; Morris, EP; Barford, D (2011-02)
      The ubiquitylation of cell-cycle regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chromatid segregation and the exit from mitosis. Selection of APC/C targets is achieved through ...