Browsing ICR Divisions by author "Bellani, Aarushi"
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The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.
Lawson, H; Holt-Martyn, JP; Dembitz, V; Kabayama, Y; Wang, LM; et al. (NATURE PORTFOLIO, 2024-06-01)Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are urgently needed. While leukemogenesis occurs in the hypoxic bone marrow, the therapeutic tractability of the hypoxia-inducible factor ...