Browsing ICR Divisions by author "Henley, Alan"
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Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Hayes, A; Mok, NY; Liu, M; Thai, C; Henley, AT; et al. (TAYLOR & FRANCIS LTD, 2017-09-01)1. We have previously described C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as cell permeable inhibitors of the KDM4 and KDM5 subfamilies of JmjC histone lysine demethylases. 2. Although exemplar compound ...