Browsing ICR Divisions by author "Harrison, Peter"
Now showing items 1-5 of 5
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A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts.
Krasny, L; Bland, P; Burns, J; Lima, NC; Harrison, PT; et al. (COMPANY BIOLOGISTS LTD, 2020-06-03)SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that ... -
Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance.
Harrison, PT; Huang, PH (PORTLAND PRESS LTD, 2018-10-26)Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding ... -
Functional characterisation of EGFR mutations in cancer
Huang, P; Harrison, P (Institute of Cancer Research (University Of London), 2021-08-31)Large-scale pan-cancer sequencing of tumour samples has identified a plethora of epidermal growth factor (EGFR) mutations along the full length of the gene. However, clinical studies have demonstrated that distinct mutations ... -
Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer.
Harrison, PT; Vyse, S; Huang, PH (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2020-04-01)Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 deletions and the L858R point mutation) ... -
Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity.
Luczynski, MT; Harrison, PT; Lima, N; Krasny, L; Paul, A; et al. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018-06-18)Discoidin Domain Receptor 2 (DDR2) is a collagen-binding receptor tyrosine kinase that initiates delayed and sustained tyrosine phosphorylation signalling. To understand the molecular basis of this unique phosphorylation ...