Now showing items 1-7 of 7

    • canSAR: an updated cancer research and drug discovery knowledgebase. 

      Tym, JE; Mitsopoulos, C; Coker, EA; Razaz, P; Schierz, AC; Antolin, AA; Al-Lazikani, B (2016-01)
      canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, ...
    • canSAR: update to the cancer translational research and drug discovery knowledgebase. 

      Coker, EA; Mitsopoulos, C; Tym, JE; Komianou, A; Kannas, C; Di Micco, P; Villasclaras Fernandez, E; Ozer, B; Antolin, AA; Workman, P; Al-Lazikani, B (2019-01)
      canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug ...
    • Dual Inhibitors of PARPs and ROCKs. 

      Antolín, AA; Mestres, J (2018-10-05)
      Recent network and system biology analyses suggest that most complex diseases are regulated by robust and highly interconnected pathways that could be better modulated by small molecules binding to multiple biological ...
    • The kinase polypharmacology landscape of clinical PARP inhibitors. 

      Antolin, AA; Ameratunga, M; Banerji, U; Clarke, PA; Workman, P; Al-Lazikani, B (2020-02-17)
      Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this is typically done within the same protein ...
    • Objective, Quantitative, Data-Driven Assessment of Chemical Probes. 

      Antolin, AA; Tym, JE; Komianou, A; Collins, I; Workman, P; Al-Lazikani, B (2018-02)
      Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting probes for biomedical research is rarely based on objective assessment of all potential compounds. Here, we ...
    • Polypharmacology in Precision Oncology: Current Applications and Future Prospects. 

      Antolin, AA; Workman, P; Mestres, J; Al-Lazikani, B (2016-01)
      Over the past decade, a more comprehensive, large-scale approach to studying cancer genetics and biology has revealed the challenges of tumor heterogeneity, adaption, evolution and drug resistance, while systems-based ...
    • Public resources for chemical probes: the journey so far and the road ahead. 

      Antolin, AA; Workman, P; Al-Lazikani, B (2019-11-28)
      High-quality small molecule chemical probes are extremely valuable for biological research and target validation. However, frequent use of flawed small-molecule inhibitors produces misleading results and diminishes the ...