Browsing ICR Divisions by author "Paschalis, Alec"

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    • Targeting androgen receptor splicing in lethal prostate cancer 

      de Bono, J; Paschalis, A (Institute of Cancer Research (University Of London), 2021-04-30)
      Over the past decade, androgen receptor (AR) directed therapies such as abiraterone and enzalutamide have become the standard of care for treating advanced prostate cancer, improving both progression-free and overall ...

    • The landscape of RNA polymerase II-associated chromatin interactions in prostate cancer. 

      Ramanand, SG; Chen, Y; Yuan, J; Daescu, K; Lambros, MB; et al. (2020-08)
      Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associated) chromatin interactions in normal prostate cells and PCa cells. We discovered thousands ...