Browsing ICR Divisions by author "Ash, Sarah"
Now showing items 1-2 of 2
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Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis.
Ash, SL; Orha, R; Mole, H; Dinesh-Kumar, M; Lee, SP; et al. (BMJ PUBLISHING GROUP, 2024-02-27)BACKGROUND: Targeting of solid cancers with chimeric antigen receptor (CAR)-T cells is limited by the lack of suitable tumor-specific antigens and the immunosuppressive, desmoplastic tumor microenvironment that impedes ... -
Targeting the tumour microenvironment with endosialin-directed CAR T-cells
Ash, S (Institute of Cancer Research (University Of London), 2022-05-31)Advances in T-cell engineering have facilitated the generation of CAR T-cells that successfully deplete malignant cells of haematological cancers. However, attempts to target solid tumours with CAR T-cells have been hindered ...