Browsing ICR Divisions by author "Tenev, Tencho"
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion, J; Gifford, V; Bellenie, B; Fernando, W; Ramos Garcia, L; et al. (Elsevier BV, 2024-05-15)Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD). Although the catalytic function of RIPK1 ...