Now showing items 1-3 of 3

    • Defining the role of SF3B1K700E mutations in ER+ breast cancer 

      Natrajan, R; Read, A (Institute of Cancer Research (University Of London), 2021-09-30)
      Mutations in SF3B1, a component of the RNA splicing machinery, underpin a number of aggressive cancers. Hotspot mutations in SF3B1 are present in around 3% of breast cancers, are enriched in oestrogen receptor positive ...
    • Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. 

      Dalton, WB; Helmenstine, E; Walsh, N; Gondek, LP; Kelkar, DS; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2019-08-08)
      Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and therapeutic consequences of this missplicing are ...
    • Splicing dysregulation as a driver of breast cancer. 

      Read, A; Natrajan, R (BIOSCIENTIFICA LTD, 2018-09-01)
      Breast cancer is known to be a heterogeneous disease driven by a large repertoire of molecular abnormalities, which contribute to its diverse clinical behaviour. Despite the success of targeted therapy approaches for breast ...