Browsing ICR Divisions by author "Tsalikis, Athanasios"
Now showing items 1-2 of 2
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Dietary omega 6/3 fats and aspirin govern PI3Ka-induced oncogenicity
Poulogiannis G; Tsalikis, A; Poulogiannis, GOncogenic mutations in PI3KCA, the gene encoding the p110a catalytic subunit of PI3K, represent one of the most frequent genetic alterations in human cancer. Although multiple inhibitors of the PI3K/AKT/mTOR pathway have ... -
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Jenks, AD; Vyse, S; Wong, JP; Kostaras, E; Keller, D; et al. (CELL PRESS, 2018-06-05)Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer ...