Browsing ICR Divisions by author "Smith, Paul"
Now showing items 1-2 of 2
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Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter
Hannigan, A; Smith, P; Kalna, G; Lo Nigro, C; Orange, C; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2010-08)The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine ... -
Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim
Paschos, K; Smith, P; Anderton, E; Middeldorp, JM; White, RE; et al. (PUBLIC LIBRARY SCIENCE, 2009-06)In human B cells infected with Epstein-Barr virus (EBV), latency-associated virus gene products inhibit expression of the proapoptotic Bcl-2-family member Bim and enhance cell survival. This involves the activities of the ...