Browsing ICR Divisions by author "Ashcroft, Margaret"
Now showing items 1-7 of 7
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Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1 alpha expression
(AMER SOC MICROBIOLOGY, 2004-04)The hypoxia-inducible factor 1 (HIF-1) transcriptional complex is regulated by cellular oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase B (PKB) pathway has been shown to regulate ... -
Hypoxia-inducible factor-1 and oncogenic signalling
(JOHN WILEY & SONS LTD, 2004-03)An understanding of underlying mechanisms Involved in the activation of HIF-1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human ... -
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms
(NATURE PUBLISHING GROUP, 2006-01)Basal telomerase activity is dependent on expression of the hTERT and hTR genes and upregulation of telomerase gene expression is associated with tumour development. It is therefore possible that signal transduction pathways ... -
Negative and positive regulation of HIF-1: A complex network
(ELSEVIER SCIENCE BV, 2005-07-25)Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis ... -
Phosphorylation of HDM2 by Akt
(2002-03-21)The HDM2 protein is a key regulator of the tumour suppressor, p53. Control of HDM2 function is critical for normal cell proliferation and stress responses, and it is becoming evident that multiple modifications of HDM2 can ... -
Role of hypoxia-inducible factor (HIF)-1 alpha-versus HIF-2 alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-1, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway
(AMER ASSOC CANCER RESEARCH, 2006-06-15)Overexpression of hypoxia-inducible factors (HIF), HIF-1 alpha and HIF-2 alpha, leads to the up-regulation of genes involved in proliferation, angiogenesis, and glucose metabolism and is associated with tumor progression ... -
Targeting the molecular basis for tumour hypoxia
(Cambridge University Press, 2005)