Browsing ICR Divisions by author "Reis-Filho, Jorge Sergio"
Now showing items 1-12 of 12
-
14-3-3 sigma stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion
(NATL ACAD SCIENCES, 2013-10-08)The protein 14-3-3s (stratifin) is frequently described as a tumor suppressor silenced in about 80% of breast tumors. Intriguingly, we show that 14-3-3s expression, which in normal breast is localized to the myoepithelial ... -
Adjuvant Therapy in Stage I Carcinoma of the Breast: The Influence of Multigene Analyses and Molecular Phenotyping
A consensus conference was held in order to provide guidelines for the use of adjuvant therapy in patients with Stage I carcinoma of the breast, using traditional information, such as tumor size, microscopic character, ... -
Breast cancer intratumor genetic heterogeneity: causes and implications
(EXPERT REVIEWS, 2012-08)There is burgeoning evidence to suggest that tumor evolution follows the laws of Darwinian evolution, whereby individual tumor cell clones harbor private genetic aberrations in addition to the founder mutations, and that ... -
Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations
(OXFORD UNIV PRESS, 2012-09)Despite improvements in adjuvant chemotherapy regimens in breast cancer; personalised use of specific cytotoxic regimens remains a clinical challenge. Defining the correct therapeutic strategy for individual patients with ... -
Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.
(2007-08)Purpose Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase overexpressed in a variety of human malignancies, against which targeted therapies have shown efficacy in lung and brain tumors. Clinical responses ... -
Prognostic signatures in breast cancer: correlation does not imply causation
(2012)Testing the statistical associations between microarray-based gene expression signatures and patient outcome has become a popular approach to infer biological and clinical significance of laboratory observations. Venet and ... -
Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
(BIOMED CENTRAL LTD, 2012)Introduction: Although the prognostic significance of proliferation in early invasive breast cancer has been recognized for a long time, recent gene-expression profiling studies have reemphasized its biologic and prognostic ... -
Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes
(WILEY, 2012-10)Aims: The aim of this study was to devise a molecular classification for salivary duct carcinomas (SDCs) based on the similarities between SDCs and breast carcinomas and on characteristics of the microarray-based gene ... -
the 11q13-q14 amplicon: Clinicopathological correlations and potential drivers
(WILEY, 2013-04)Amplification at 11q13-q14 is a common event in cancers from multiple anatomical sites. This complex amplicon has multiple cores and several genes have been put forward as potential drivers. In this review, based on the ... -
The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers.
(2010-03)We hypothesized that the functional status of p53 transcriptional pathways, rather than p53 protein expression alone, could accurately discriminate between low- and high-risk breast carcinoma (BC) and inform about individuals' ... -
The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade.
(2010-01)In the last decade, the development of microarrays and the ability to perform massively parallel gene expression analysis of human tumours were received with great excitement by the scientific community. The promise of ... -
Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas.
(2010-09)Tubular carcinoma (TC) is an uncommon special type of breast cancer characterized by an indolent clinical course. Although described as part of a spectrum of related lesions named 'low-grade breast neoplasia family' due ...
