Browsing ICR Divisions by author "Saunders, Charles"
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Frequency of pathogenic germline variants in cancer susceptibility genes in 1336 renal cell carcinoma cases.
Yngvadottir, B; Andreou, A; Bassaganyas, L; Larionov, A; Cornish, AJ; et al. (OXFORD UNIV PRESS, 2022-08-25)Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes, but the genetic architecture of susceptibility to RCC is not well defined. We investigated the frequency of pathogenic and likely pathogenic ... -
Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis.
Saunders, CN; Cornish, AJ; Kinnersley, B; Law, PJ; Claus, EB; et al. (OXFORD UNIV PRESS INC, 2019-10-30)BACKGROUND: The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian randomization (MR) framework to examine if lifestyle, cardiometabolic, and inflammatory factors influence the ... -
Relationship between genetically determined telomere length and glioma risk.
Saunders, CN; Kinnersley, B; Culliford, R; Cornish, AJ; Law, PJ; et al. (OXFORD UNIV PRESS INC, 2022-02-01)BACKGROUND: Telomere maintenance is increasingly recognized as being fundamental to glioma oncogenesis with longer leukocyte telomere length (LTL) reported to increase risk of glioma. To gain further insight into the ... -
Search for AL amyloidosis risk factors using Mendelian randomization.
Saunders, CN; Chattopadhyay, S; Huhn, S; Weinhold, N; Hoffmann, P; et al. (ELSEVIER, 2021-07-13)In amyloid light chain (AL) amyloidosis, amyloid fibrils derived from immunoglobulin light chain are deposited in many organs, interfering with their function. The etiology of AL amyloidosis is poorly understood. Summary ... -
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.
Saunders, CN; Cornish, AJ; Kinnersley, B; Law, PJ; Houlston, RS; et al. (SPRINGERNATURE, 2021-01-19)BACKGROUND: The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma ...