Now showing items 1-3 of 3

    • BRD4 facilitates replication stress-induced DNA damage response. 

      Zhang, J; Dulak, AM; Hattersley, MM; Willis, BS; Nikkilä, J; Wang, A; Lau, A; Reimer, C; Zinda, M; Fawell, SE; Mills, GB; Chen, H (2018-07)
      Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and ...
    • Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links. 

      Rickman, KA; Noonan, RJ; Lach, FP; Sridhar, S; Wang, AT; Abhyankar, A; Huang, A; Kelly, M; Auerbach, AD; Smogorzewska, A (2020-06)
      DNA interstrand cross-links (ICLs) are a form of DNA damage that requires the interplay of a number of repair proteins including those of the Fanconi anemia (FA) and the homologous recombination (HR) pathways. Pathogenic ...
    • SLFN11 informs on standard of care and novel treatments in a wide range of cancer models. 

      Winkler, C; Armenia, J; Jones, GN; Tobalina, L; Sale, MJ; Petreus, T; Baird, T; Serra, V; Wang, AT; Lau, A; Garnett, MJ; Jaaks, P; Coker, EA; Pierce, AJ; O'Connor, MJ; Leo, E
      <h4>Background</h4>Schlafen 11 (SLFN11) has been linked with response to DNA-damaging agents (DDA) and PARP inhibitors. An in-depth understanding of several aspects of its role as a biomarker in cancer is missing, as is a ...