Browsing ICR Divisions by author "Fletcher, Catherine"
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Combining large scale in silico analysis with fragment screening to identify novel, ligandable secondary sites in cancer-associated proteins
van Montfort, R; Fletcher, C (Institute of Cancer Research (University Of London), 2020-01-31)Proteins often have multiple binding sites involved in interactions with other molecules. The majority of currently approved drugs bind a protein's primary site, the major functional site in the protein. Targeting the ...