Browsing ICR Divisions by author "Shrestha, Sumana"
Now showing items 1-2 of 2
-
Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead.
Shrestha, S; Morcavallo, A; Gorrini, C; Chesler, L (FRONTIERS MEDIA SA, 2021-06-14)The constitutive and dysregulated expression of the transcription factor MYCN has a central role in the pathogenesis of the paediatric brain tumour medulloblastoma, with an increased expression of this oncogene correlating ... -
Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models.
Tucker, ER; Jiménez, I; Chen, L; Bellini, A; Gorrini, C; et al. (AMER ASSOC CANCER RESEARCH, 2023-04-03)PURPOSE: ALK-activating mutations are identified in approximately 10% of newly diagnosed neuroblastomas and ALK amplifications in a further 1%-2% of cases. Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK) ...