Browsing ICR Divisions by author "James, Chela"
Now showing items 1-4 of 4
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Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia.
Turati, VA; Guerra-Assunção, JA; Potter, NE; Gupta, R; Ecker, S; et al. (NATURE PORTFOLIO, 2021-07-05)Comparison of intratumor genetic heterogeneity in cancer at diagnosis and relapse suggests that chemotherapy induces bottleneck selection of subclonal genotypes. However, evolutionary events subsequent to chemotherapy could ... -
Circulating tumour DNA sequencing to determine therapeutic response and identify tumour heterogeneity in patients with paediatric solid tumours.
Stankunaite, R; George, SL; Gallagher, L; Jamal, S; Shaikh, R; et al. (ELSEVIER SCI LTD, 2021-12-18)OBJECTIVE: Clinical diagnostic sequencing of circulating tumour DNA (ctDNA) is well advanced for adult patients, but application to paediatric cancer patients lags behind. METHODS: To address this, we have developed a ... -
Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells.
Rosano, D; Sofyali, E; Dhiman, H; Ghirardi, C; Ivanoiu, D; et al. (AMER ASSOC CANCER RESEARCH, 2024-05-01)UNLABELLED: Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients ... -
The co-evolution of the genome and epigenome in colorectal cancer
Sottoriva, A; Heide, T; Cresswell, G; Spiteri, I; Lynn, C; et al. (2021-07-12)Colorectal malignancies are a leading cause of cancer death. Despite large-scale genomic efforts, DNA mutations do not fully explain malignant evolution. Here we study the co-evolution of the genome and epigenome of ...