Browsing ICR Divisions by author "Nenclares, Pablo"
Now showing items 1-10 of 10
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Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer.
Angelis, V; Tippu, Z; Joshi, K; Reis, S; Gronthoud, F; et al. (ELSEVIER SCI LTD, 2020-09-01)BACKGROUND: In light of the coronavirus disease 2019 (COVID-19) pandemic, cancer centres in the United Kingdom and Europe re-organised their services at an unprecedented pace, and many patients with cancer have had their ... -
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation.
Dillon, MT; Guevara, J; Mohammed, K; Patin, EC; Smith, SA; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2024-01-16)BACKGROUNDPhase 1 study of ATRinhibition alone or with radiation therapy (PATRIOT) was a first-in-human phase I study of the oral ATR (ataxia telangiectasia and Rad3-related) inhibitor ceralasertib (AZD6738) in advanced ... -
FUME-TCRseq enables sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNA.
Baker, A-M; Nageswaran, G; Nenclares, P; Ronel, T; Smith, K; et al. (American Association for Cancer Research, 2024-03-14)Genomic analysis of the T-cell receptor (TCR) reveals the strength, breadth, and clonal dynamics of the adaptive immune response to pathogens or cancer. The diversity of the TCR repertoire, however, means that sequencing ... -
Harnessing radiotherapy-induced NK-cell activity by combining DNA damage-response inhibition and immune checkpoint blockade.
Patin, EC; Dillon, MT; Nenclares, P; Grove, L; Soliman, H; et al. (BMJ PUBLISHING GROUP, 2022-03-01)BACKGROUND: Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell ... -
Head and neck mucosal melanoma: The United Kingdom national guidelines.
Nenclares, P; Ap Dafydd, D; Bagwan, I; Begg, D; Kerawala, C; et al. (ELSEVIER SCI LTD, 2020-10-01)The United Kingdom head and neck mucosal melanoma guideline development group used an evidence-based systematic approach to make recommendations in key areas of uncertainty in the field, including accurate diagnosis and ... -
Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy.
Nenclares, P; Bhide, SA; Sandoval-Insausti, H; Pialat, P; Gunn, L; et al. (ELSEVIER SCI LTD, 2020-05-01)BACKGROUND: Pre-clinical evidence suggests reduced efficacy of anticancer treatment in patients exposed to broad-spectrum antibiotics. It is hypothesised that this phenomenon may be explained by the effects of antibiotics ... -
Looking a Gift Horse in the Mouth: Observations on NHS England's Interim Guidance on Pembrolizumab in Head and Neck Squamous Cell Cancer.
Harrington, KJ; Bhide, SA; Forster, MD; Good, JS; Gunn, L; et al. (2020-08) -
On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy.
Nenclares, P; Gunn, L; Soliman, H; Bover, M; Trinh, A; et al. (BMJ PUBLISHING GROUP, 2021-06-01)BACKGROUND: Previous studies have suggested that inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH) and fibrinogen) are prognostic biomarkers in patients with a variety of solid cancers, ... -
Systemic biomarkers of immune response in locally-advanced human papillomavirus malignancies treated with radical chemoradiation
Bhide S; Nenclares, P; Bhide, S (Institute of Cancer Research (University Of London), 2024-02-19)Human papillomavirus (HPV)-driven malignancies exhibit viral oncogenic proteins that act as tumour-specific antigens, making them suitable candidates for monitoring the adaptive immune response during treatment. Chemoradiation ... -
Taste dysfunction following radiotherapy to the head and neck: A systematic review.
Gunn, L; Gilbert, J; Nenclares, P; Soliman, H; Newbold, K; et al. (ELSEVIER IRELAND LTD, 2021-04-01)BACKGROUND: An intact sense of taste provides pleasure, supports sustenance and alerts the body to toxins. Head and neck cancer (HNC) patients who receive radiotherapy (RT) are high-risk for developing radiation-induced ...