Browsing ICR Divisions by author "Mannion, Jonathan"
Now showing items 1-2 of 2
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion, J; Gifford, V; Bellenie, B; Fernando, W; Ramos Garcia, L; et al. (Elsevier BV, 2024-05-15)Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD). Although the catalytic function of RIPK1 ... -
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
Ciuffa, R; Uliana, F; Mannion, J; Mehnert, M; Tenev, T; et al. (NATL ACAD SCIENCES, 2022-10-04)Protein-protein interactions (PPIs) represent the main mode of the proteome organization in the cell. In the last decade, several large-scale representations of PPI networks have captured generic aspects of the functional ...