Browsing ICR Divisions by author "Gear, Jonathan"
Now showing items 1-20 of 24
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A Systematic Review and Meta-Analysis of the Relationship Between the Radiation Absorbed Dose to the Thyroid and Response in Patients Treated with Radioiodine for Graves' Disease.
Taprogge, J; Gape, PMD; Carnegie-Peake, L; Murray, I; Gear, JI; et al. (MARY ANN LIEBERT, INC, 2021-12-01)Background: Patients with Graves' disease are commonly treated with radioiodine. There remains controversy over whether the aim of treatment should be to achieve euthyroidism or hypothyroidism, and whether treatments should ... -
Abdo-Man: a 3D-printed anthropomorphic phantom for validating quantitative SIRT.
Gear, JI; Cummings, C; Craig, AJ; Divoli, A; Long, CDC; et al. (SPRINGER, 2016-08-05)BACKGROUND: The use of selective internal radiation therapy (SIRT) is rapidly increasing, and the need for quantification and dosimetry is becoming more widespread to facilitate treatment planning and verification. The aim ... -
Adjustment of the iodine ICRP population pharmacokinetic model for the use in thyroid cancer patients after thyroidectomy.
Taprogge, J; Carnegie-Peake, L; Murray, I; Gear, JI; Flux, GD (IOP Publishing Ltd, 2021-11-11)Biokinetic models developed for healthy humans are not appropriate to describe biokinetics in thyroid cancer patients following thyroidectomy. The aim of this study was to adjust the population model for iodine proposed ... -
Characterisation of the attenuation properties of 3D-printed tungsten for use in gamma camera collimation.
Gear, JI; Taprogge, J; White, O; Flux, GD (SPRINGER, 2019-01-07)BACKGROUND: The aim of this work was to characterise the attenuation properties of 3D-printed tungsten and to assess the feasibility for its use in gamma camera collimator manufacture. METHOD: 3D-printed tungsten disks ... -
Comparison of 90Y SIRT predicted and delivered absorbed doses using a PSF conversion method.
Craig, AJ; Murray, I; Denis-Bacelar, AM; Rojas, B; Gear, JI; et al. (ELSEVIER SCI LTD, 2021-07-30)PURPOSE: The aims of this study were to develop and apply a method to correct for the differences in partial volume effects of pre-therapy Technetium-99 m (99mTc)-MAA SPECT and post-therapy Yttrium-90 (90Y) bremsstrahlung ... -
Compartmental Model for 223Ra-Dichloride in Patients With Metastatic Bone Disease From Castration-Resistant Prostate Cancer.
Taprogge, J; Murray, I; Gear, J; Chittenden, SJ; Parker, CC; et al. (ELSEVIER SCIENCE INC, 2018-06-04)PURPOSE: 223Ra-Dichloride is used for treatment of patients with metastatic bone disease from castration-resistant prostate cancer. The uptake and mechanism of action of 223Ra-Dichloride is not well understood. The aim of ... -
EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for 131I mIBG treatment of neuroendocrine tumours.
Gear, J; Chiesa, C; Lassmann, M; Gabiña, PM; Tran-Gia, J; et al. (SPRINGEROPEN, 2020-03-06)The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Dosimetry" (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose assessments. ... -
EANM dosimetry committee series on standard operational procedures: a unified methodology for 99mTc-MAA pre- and 90Y peri-therapy dosimetry in liver radioembolization with 90Y microspheres.
Chiesa, C; Sjogreen-Gleisner, K; Walrand, S; Strigari, L; Flux, G; et al. (SPRINGER, 2021-11-12)The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in 90Y microsphere liver radioembolization. Basic assumptions ... -
EANM enabling guide: how to improve the accessibility of clinical dosimetry.
Gear, J; Stokke, C; Terwinghe, C; Gnesin, S; Sandström, M; et al. (SPRINGER, 2023-04-22)Dosimetry can be a useful tool for personalization of molecular radiotherapy (MRT) procedures, enabling the continuous development of theranostic concepts. However, the additional resource requirements are often seen as a ... -
EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations.
Gear, JI; Cox, MG; Gustafsson, J; Gleisner, KS; Murray, I; et al. (SPRINGER, 2018-12-01)A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed ... -
Effects of Respiratory Motion on Y-90 PET Dosimetry for SIRT.
Walker, MD; Gear, JI; Craig, AJ; McGowan, DR (MDPI, 2022-01-14)Respiratory motion degrades the quantification accuracy of PET imaging by blurring the radioactivity distribution. In the case of post-SIRT PET-CT verification imaging, respiratory motion can lead to inaccuracies in ... -
Eighty per cent more patients in 10 years of UK molecular radiotherapy: Internal Dosimetry Users Group survey results from 2007 to 2017.
Rojas, B; McGowan, DR; Guy, MJ; Tipping, J; Aldridge, M; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2019-07-01) -
From fixed activities to personalized treatments in radionuclide therapy: lost in translation?
Flux, GD; Sjogreen Gleisner, K; Chiesa, C; Lassmann, M; Chouin, N; et al. (SPRINGER, 2018-01-01) -
InfuShield: a shielded enclosure for administering therapeutic radioisotope treatments using standard syringe pumps.
Rushforth, DP; Pratt, BE; Chittenden, SJ; Murray, IS; Causer, L; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2017-03-01)The administration of radionuclide therapies presents significant radiation protection challenges. The aim of this work was to develop a delivery system for intravenous radioisotope therapies to substantially moderate ... -
Inter-comparison of quantitative imaging of lutetium-177 (177Lu) in European hospitals.
Wevrett, J; Fenwick, A; Scuffham, J; Johansson, L; Gear, J; et al. (SPRINGEROPEN, 2018-08-02)BACKGROUND: This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (177Lu) in current clinical practice. Our aim was to assess the feasibility of using ... -
Milestones in dosimetry for nuclear medicine therapy.
Gear, J (Oxford University Press (OUP), 2022-07-01)Nuclear Medicine therapy has reached a critical juncture with an unprecedented number of patients being treated and an extensive list of new radiopharmaceuticals under development. Since the early applications of these ... -
Objective comparison of lesion detectability in low and medium-energy collimator iodine-123 mIBG images using a channelized Hotelling observer.
Gregory, RA; Murray, I; Gear, J; Aldridge, MD; Levine, D; et al. (IOP PUBLISHING LTD, 2017-01-07)Iodine-123 mIBG imaging is widely regarded as a gold standard for diagnostic studies of neuroblastoma and adult neuroendocrine cancer although the optimal collimator for tumour imaging remains undetermined. Low-energy (LE) ... -
Quantification and dosimetry of small volumes including associated uncertainty estimation.
Carnegie-Peake, L; Taprogge, J; Murray, I; Flux, GD; Gear, J (SPRINGER, 2022-12-13)BACKGROUND: Accurate quantification of radioactivity in a source of interest relies on accurate registration between SPECT and anatomical images, and appropriate correction of partial volume effects (PVEs). For small ... -
Quantitative Dual-Isotope Planar Imaging of Thorium-227 and Radium-223 Using Defined Energy Windows.
Murray, I; Rojas, B; Gear, J; Callister, R; Cleton, A; et al. (MARY ANN LIEBERT, INC, 2020-09-01)Introduction: Thorium-227 is an alpha-emitting radioisotope with potential therapeutic applications in targeted alpha therapy. Thorium-227 decays to Radium-223, which may have an independent biodistribution to that of the ... -
Radioactive 3D printing for the production of molecular imaging phantoms.
Gear, JI; Cummings, C; Sullivan, J; Cooper-Rayner, N; Downs, P; et al. (IOP Publishing Ltd, 2020-09-08)Quality control tests of molecular imaging systems are hampered by the complexity of phantom preparation. It is proposed that radioisotopes can be directly incorporated into photo-polymer resins. Use of the radio-polymer ...