Browsing ICR Divisions by author "Wasti, Ajla"
Now showing items 1-4 of 4
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A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.
George, SL; Izquierdo, E; Campbell, J; Koutroumanidou, E; Proszek, P; et al. (ELSEVIER SCI LTD, 2019-11-01)BACKGROUND: For children with cancer, the clinical integration of precision medicine to enable predictive biomarker-based therapeutic stratification is urgently needed. METHODS: We have developed a hybrid-capture next-generation ... -
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.
Rajagopalan, KN; Egnatchik, RA; Calvaruso, MA; Wasti, AT; Padanad, MS; et al. (Springer Science and Business Media LLC, 2015-01-01)BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. ... -
Mini-Review on Targeted Treatment of Desmoplastic Small Round Cell Tumor.
Bexelius, TS; Wasti, A; Chisholm, JC (FRONTIERS MEDIA SA, 2020-04-21)Desmoplastic small round cell tumor (DSRCT) is a devastating disease which most commonly affects adolescents, with a male predominance. Despite the best multimodality treatment efforts, most patients will ultimately not ... -
Molecular Characterization of Circulating Tumor DNA in Pediatric Rhabdomyosarcoma: A Feasibility Study.
Ruhen, O; Lak, NSM; Stutterheim, J; Danielli, SG; Chicard, M; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2022-10-01)PURPOSE: Rhabdomyosarcomas (RMS) are rare neoplasms affecting children and young adults. Efforts to improve patient survival have been undermined by a lack of suitable disease markers. Plasma circulating tumor DNA (ctDNA) ...