Browsing ICR Divisions by author "Downward, Julian David Harry"
Now showing items 21-28 of 28
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RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression.
Castellano, E; Molina-Arcas, M; Krygowska, AA; East, P; Warne, P; et al. (2016-04-13)RAS signalling through phosphoinositide 3-kinase (PI3-Kinase) has been shown to have an essential role in tumour initiation and maintenance. RAS also regulates cell motility and tumour invasiveness, but the role of direct ... -
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.
Caswell, DR; Gui, P; Mayekar, MK; Law, EK; Pich, O; et al. (NATURE PORTFOLIO, 2024-01-01)In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR mutant ... -
SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity.
Liu, H; Ertay, A; Peng, P; Li, J; Liu, D; et al. (2019-09)Sodium/glucose cotransporter 1 (SGLT1), an essential active glucose transport protein that helps maintain high intracellular glucose levels, was previously shown to interact with epidermal growth factor receptor (EGFR); ... -
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.
Jones, GG; Del Río, IB; Sari, S; Sekerim, A; Young, LC; et al. (2019-06-10)Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in ... -
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.
Mathew, G; Hannan, A; Hertzler-Schaefer, K; Wang, F; Feng, G-S; et al. (2016-11)Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlying cause of PTEN hamartoma tumor syndrome and a wide variety of human cancers. In skin epidermis, we have previously identified ... -
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.
Mugarza, E; van Maldegem, F; Boumelha, J; Moore, C; Rana, S; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2022-07-22)Recently developed KRASG12C inhibitory drugs are beneficial to lung cancer patients harboring KRASG12C mutations, but drug resistance frequently develops. Because of the immunosuppressive nature of the signaling network ... -
Tumour-suppression function of KLF12 through regulation of anoikis.
Godin-Heymann, N; Brabetz, S; Murillo, MM; Saponaro, M; Santos, CR; et al. (2016-06)Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, ... -
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.
Ertay, A; Liu, H; Liu, D; Peng, P; Hill, C; et al. (2020-11-21)Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer that lacks the oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, making it difficult to target ...