Browsing ICR Divisions by author "Roumeliotis, Theodoros"
Now showing items 21-29 of 29
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Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression.
Chen, Y-J; Roumeliotis, TI; Chang, Y-H; Chen, C-T; Han, C-L; et al. (CELL PRESS, 2020-07-09)Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this demographically distinct disease, we performed a ... -
Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition.
Beykou, M; Arias-Garcia, M; Roumeliotis, TI; Choudhary, JS; Moser, N; et al. (NATURE PORTFOLIO, 2022-07-11)When used in combination with hormone treatment, Palbociclib prolongs progression-free survival of patients with hormone receptor positive breast cancer. Mechanistically, Palbociclib inhibits CDK4/6 activity but the basis ... -
SimPLIT: Simplified Sample Preparation for Large-Scale Isobaric Tagging Proteomics.
Sialana, FJ; Roumeliotis, TI; Bouguenina, H; Chan Wah Hak, L; Wang, H; et al. (AMER CHEMICAL SOC, 2022-08-05)Large scale proteomic profiling of cell lines can reveal molecular signatures attributed to variable genotypes or induced perturbations, enabling proteogenomic associations and elucidation of pharmacological mechanisms of ... -
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines.
Cano-Gamez, E; Soskic, B; Roumeliotis, TI; So, E; Smyth, DJ; et al. (NATURE RESEARCH, 2020-04-14)Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, ... -
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.
Llorca-Cardenosa, MJ; Aronson, LI; Krastev, DB; Nieminuszczy, J; Alexander, J; et al. (AMER ASSOC CANCER RESEARCH, 2022-11-02)UNLABELLED: Gastric cancer represents the third leading cause of global cancer mortality and an area of unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors (ATRi), have been proposed ... -
Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling.
Koliopoulos, MG; Muhammad, R; Roumeliotis, TI; Beuron, F; Choudhary, JS; et al. (NATURE PORTFOLIO, 2022-08-29)Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of protein complexes in a cell cycle-specific manner. Complexes of MuvB with the transcription factors B-MYB and FOXM1 activate ... -
The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.
Berger, CN; Crepin, VF; Roumeliotis, TI; Wright, JC; Serafini, N; et al. (PUBLIC LIBRARY SCIENCE, 2018-10-01)Infection with Citrobacter rodentium triggers robust tissue damage repair responses, manifested by secretion of IL-22, in the absence of which mice succumbed to the infection. Of the main hallmarks of C. rodentium infection ... -
The proteomic landscape of soft tissue sarcomas.
Burns, J; Wilding, CP; Krasny, L; Zhu, X; Chadha, M; et al. (NATURE PORTFOLIO, 2023-06-29)Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological ... -
Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.
Steinberg, J; Brooks, RA; Southam, L; Bhatnagar, S; Roumeliotis, TI; et al. (OXFORD UNIV PRESS, 2018-08-01)OBJECTIVES: To identify molecular differences between chondrocytes from osteophytic and articular cartilage tissue from OA patients. METHODS: We investigated genes and pathways by combining genome-wide DNA methylation, RNA ...