Browsing ICR Divisions by author "Furness, Andrew"
Now showing items 21-35 of 35
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Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways.
Spain, L; Coulton, A; Lobon, I; Rowan, A; Schnidrig, D; et al. (AMER ASSOC CANCER RESEARCH, 2023-06-02)UNLABELLED: Understanding the evolutionary pathways to metastasis and resistance to immune-checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present the most comprehensive intrapatient ... -
Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma.
Alrasheed, N; Lee, L; Ghorani, E; Henry, JY; Conde, L; et al. (AMER ASSOC CANCER RESEARCH, 2020-07-01)PURPOSE: Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the contribution of immune dysfunction to clinical outcomes remains ... -
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.
Litchfield, K; Reading, JL; Puttick, C; Thakkar, K; Abbosh, C; et al. (CELL PRESS, 2021-02-04)Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization. Here, we ... -
Multiple paternity in superfetatious live-bearing fishes.
Dekker, ML; van Son, LM; Leon-Kloosterziel, KM; Hagmayer, A; Furness, AI; et al. (WILEY, 2022-05-25)Superfetation, the ability to carry several overlapping broods at different developmental stages, has evolved independently multiple times within the live-bearing fish family Poeciliidae. Even though superfetation is ... -
Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander, JL; Ibraheim, H; Richards, C; Shum, B; Pavlidis, P; et al. (BMJ PUBLISHING GROUP, 2022-09-01)INTRODUCTION: Systemic corticosteroids are the mainstay of treatment for immune checkpoint inhibitor induced (CPI) colitis but are associated with complications including life-threatening infection. The topically acting ... -
Pan-cancer deconvolution of tumour composition using DNA methylation.
Chakravarthy, A; Furness, A; Joshi, K; Ghorani, E; Ford, K; et al. (NATURE PUBLISHING GROUP, 2018-08-13)The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated ... -
The reproductive ecology drivers of egg attendance in amphibians.
Furness, AI; Capellini, I (WILEY, 2022-10-01)Parental care is extremely diverse but, despite much research, why parental care evolves is poorly understood. Here we address this outstanding question using egg attendance, the simplest and most common care form in many ... -
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer.
Wu, MY; Shepherd, STC; Fendler, A; Carr, EJ; Au, L; et al. (CELL PRESS, 2023-05-08)Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants. -
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study.
Fu, X; Zhao, Y; Lopez, JI; Rowan, A; Au, L; et al. (NATURE PORTFOLIO, 2022-01-01)Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification in clear cell ... -
Terrestrial reproduction and parental care drive rapid evolution in the trade-off between offspring size and number across amphibians.
Furness, AI; Venditti, C; Capellini, I; Jennions MD (Public Library of Science (PLoS), 2022-01-01)The trade-off between offspring size and number is central to life history strategies. Both the evolutionary gain of parental care or more favorable habitats for offspring development are predicted to result in fewer, ... -
The melanoma-specific graded prognostic assessment does not adequately discriminate prognosis in a modern population with brain metastases from malignant melanoma.
Wilkins, A; Furness, A; Corbett, RW; Bloomfield, A; Porta, N; et al. (NATURE PUBLISHING GROUP, 2015-11-03)BACKGROUND: The melanoma-specific graded prognostic assessment (msGPA) assigns patients with brain metastases from malignant melanoma to 1 of 4 prognostic groups. It was largely derived using clinical data from patients ... -
The role of systemic therapy in paediatric cutaneous melanoma: a review
Chisholm, J; Corley, E; Furness, A; Schmitt, A -
The spectrum of cardiovascular complications related to immune-checkpoint inhibitor treatment : Including myocarditis and the new entity of non inflammatory left ventricular dysfunction.
Andres, MS; Ramalingam, S; Rosen, SD; Baksi, J; Khattar, R; et al. (BMC, 2022-11-24)BACKGROUND: The full range of cardiovascular complications related to the use of Immune checkpoint inhibitors (ICI) is not fully understood. We aim to describe the spectrum of cardiovascular adverse events (cvAEs) by ... -
Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment.
Wong, YNS; Joshi, K; Khetrapal, P; Ismail, M; Reading, JL; et al. (ROCKEFELLER UNIV PRESS, 2018-11-05)Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational ... -
'You give me fever!': are health services ready for immune cell engager therapy in advanced solid malignancies?
Pettinger, C; Livings, C; Grochot, R; Furness, A; Lopez, J (BMJ PUBLISHING GROUP, 2022-12-01)Immune cell engager therapeutic strategies using bioengineered molecules to redirect immune cells into tumor are starting to demonstrate promising clinical activity in multiple early phase trials across numerous targets ...