Browsing ICR Divisions by title

Toward personalized treatment in multiple myeloma based on molecular characteristics.

Pawlyn, C; Davies, FE (2019-02)

To date, the choice of therapy for an individual multiple myeloma patient has been based on clinical factors such as age and comorbidities. The widespread evolution, validation, and clinical utilization of molecular ...

Toward Point-of-care Uropathogen Detection Using SERS Active Filters

Dryden, SD; Anastasova, S; Satta, G; Thompson, AJ; Leff, DR; et al. (SPIE-INT SOC OPTICAL ENGINEERING, 2020-01-01)

Towards an evidence-based model of fear of cancer recurrence for breast cancer survivors.

Custers, JAE; Gielissen, MFM; de Wilt, JHW; Honkoop, A; Smilde, TJ; et al. (2017-02)

Purpose In order to understand the multidimensional mechanism of fear of cancer recurrence (FCR) and to identify potential targets for interventions, it is important to empirically test the theoretical model of FCR. This ...

Towards Precision Medicine in the Clinic: From Biomarker Discovery to Novel Therapeutics.

Collins, DC; Sundar, R; Lim, JSJ; Yap, TA (2017-01)

Precision medicine continues to be the benchmark to which we strive in cancer research. Seeking out actionable aberrations that can be selectively targeted by drug compounds promises to optimize treatment efficacy and ...

Towards Real Time Radiotherapy Simulation

Voss, N; Ziegenhein, P; Vermond, L; Hoozemans, J; Mencer, O; et al. (SPRINGER, 2020-06-27)

Towards real-time photon Monte Carlo dose calculation in the cloud.

Ziegenhein, P; Kozin, IN; Kamerling, CP; Oelfke, U (2017-06)

Near real-time application of Monte Carlo (MC) dose calculation in clinic and research is hindered by the long computational runtimes of established software. Currently, fast MC software solutions are available utilising ...

Towards the evaluation of the relevant degrees of freedom in nonlinear partial differential equations

Degenhard, A; Rodriguez-Laguna, J (SPRINGER, 2002-03)

We investigate an operator renormalization group method to extract and describe the relevant degrees of freedom in the evolution of partial differential equations. The proposed renormalization group approach is formulated ...

Towards ultrasound-guided adaptive radiotherapy for cervical cancer: Evaluation of Elekta's semiautomated uterine segmentation method on 3D ultrasound images.

Mason, SA; O'Shea, TP; White, IM; Lalondrelle, S; Downey, K; et al. (2017-07)

Purpose 3D ultrasound (US) images of the uterus may be used to adapt radiotherapy (RT) for cervical cancer patients based on changes in daily anatomy. This requires accurate on-line segmentation of the uterus. The aim of ...

Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL).

Dearnaley, D; Griffin, CL; Lewis, R; Mayles, P; Mayles, H; et al. (2019-03)

Purpose To establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely deliverable at multiple centers.Methods and materials In this phase ...

Toxicity and Survival Outcomes of a Randomized Phase 2 Trial of Hypofractionated Bladder Radiation Therapy in an Elderly Population With or Without Image Guided Adaptive Plan Selection (HYBRID - CRUK/12/055)

Huddart, RA; Henry, A; Khoo, V; Staffurth, J; Syndikus, I; et al. (ELSEVIER SCIENCE INC, 2017-10-01)

TP53 MODULATES RADIOTHERAPY FRACTION SIZE SENSITIVITY IN NORMAL AND MALIGNANT CELLS

Somaiah, N; Yarnold, J; Anbalagan, S; Harrington, K; Downs, J; et al.

TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia

(2014-10)

Purpose: The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whether TP53 mutational status confers ...

TPL-2-Mediated Activation of MAPK Downstream of TLR4 Signaling Is Coupled to Arginine Availability

Mieulet, V; Yan, L; Choisy, C; Sully, K; Procter, J; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2010-08-17)

The innate immune response is influenced by the nutrient status of the host. Mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase 1 (ERK1) and ERK2, are activated after the stimulation ...

TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).

Muller, I; Kilburn, LS; Taylor, PN; Barrett-Lee, PJ; Bliss, JM; et al. (2017-07)

Background Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome.Objectives We aimed to clarify this association in a large cohort using the phase III, ...

Traceable reference dosimetry in MRI guided radiotherapy using alanine: calibration and magnetic field correction factors of ionisation chambers.

Billas, I; Bouchard, H; Oelfke, U; Duane, S (2021-05-28)

MRIgRT falls outside the scope of existing CoPs, because do not consider the effects of the magnetic field on detector response and on absorbed dose to water. The aim of this study is to evaluate and demonstrate the traceable ...

Tracking the molecular and metabolic fingerprints of inhalational versus intravenous anaesthetics in preclinical models of breast cancer

Poulogiannis, G; Perry, N (Institute of Cancer Research (University Of London), 2021-09-30)

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Publications Repository