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Now showing items 2021-2028 of 2028
Recognising the challenges of implementing multi-centre adaptive plan of the day radiotherapy.
(ELSEVIER, 2022-03-01)
Two multicentre adaptive radiotherapy trials utilising Plan of the Day (PoD) with a library of plans were introduced in 35 centres. The common issues that arose from all centres when introducing PoD were collated ...
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
(NATURE PORTFOLIO, 2023-10-02)
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data ...
HER3 Is an Actionable Target in Advanced Prostate Cancer.
(AMER ASSOC CANCER RESEARCH, 2021-12-15)
It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically. However, we show here that ...
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel.
(BMJ PUBLISHING GROUP, 2023-11-27)
BACKGROUND: Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European ...
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.
(WILEY, 2023-08-01)
BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. AIM: To assessed the ...
A Review of the Metrics Used to Assess Auto-Contouring Systems in Radiotherapy.
(ELSEVIER SCIENCE LONDON, 2023-01-31)
Auto-contouring could revolutionise future planning of radiotherapy treatment. The lack of consensus on how to assess and validate auto-contouring systems currently limits clinical use. This review formally quantifies the ...
Position statement on clinical evaluation of imaging AI.
(ELSEVIER, 2023-07-01)
Artificial Intelligence for Radiotherapy Auto-Contouring: Current Use, Perceptions of and Barriers to Implementation.
(ELSEVIER SCIENCE LONDON, 2023-01-01)
AIMS: Artificial intelligence has the potential to transform the radiotherapy workflow, resulting in improved quality, safety, accuracy and timeliness of radiotherapy delivery. Several commercially available artificial ...