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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.
(FRONTIERS MEDIA SA, 2020-10-08)
Cancer somatic mutations have been identified as a source of antigens that can be targeted by cancer immunotherapy. In this work, expanding on previous studies, we analyze the HLA-presentation properties of mutations that ...
CdTe Based Energy Resolving, X-ray Photon Counting Detector Performance Assessment: The Effects of Charge Sharing Correction Algorithm Choice.
(MDPI, 2020-10-27)
Most modern energy resolving, photon counting detectors employ small (sub 1 mm) pixels for high spatial resolution and low per pixel count rate requirements. These small pixels can suffer from a range of charge sharing ...
The Effects of Spectral X-Ray Photon Counting Detector Parameters on Detector Performance: Thickness and Pitch
(IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2020-01-01)
Exposure-Response and Population Pharmacokinetic Analyses of a Novel Subcutaneous Formulation of Daratumumab Administered to Multiple Myeloma Patients.
(WILEY, 2020-11-03)
We report the population pharmacokinetic (PK) and exposure-response analyses of a novel subcutaneous formulation of daratumumab (DARA) using data from 3 DARA subcutaneous monotherapy studies (PAVO Part 2, MMY1008, COLUMBA) ...
Stereotactic radiotherapy with focal boost for intermediate and high-risk prostate cancer: Initial results of the SPARC trial.
(ELSEVIER IRELAND LTD, 2020-11-01)
INTRODUCTION: Dose escalation to dominant intraprostatic lesions (DILs) is a novel method to increase the therapeutic ratio in localised prostate cancer. The Stereotactic Prostate Augmented Radiotherapy with Cyberknife ...
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells.
(eLife Sciences Publications, Ltd, 2020-09-10)
SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. ...
Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo.
(CELL PRESS, 2020-11-16)
Many protein-modifying enzymes recognize their substrates via docking motifs, but the range of functionally permissible motif sequences is often poorly defined. During eukaryotic cell division, cyclin-specific docking ...
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1).
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2020-06-12)
Protein kinase B (AKT1) is a central node in a signaling pathway that regulates cell survival. The diverse pathways regulated by AKT1 are communicated in the cell via the phosphorylation of perhaps more than 100 cellular ...
DisProt: intrinsic protein disorder annotation in 2020.
(OXFORD UNIV PRESS, 2020-01-08)
The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version ...
PIVOT-10: Phase II study of bempegaldesleukin plus nivolumab in cisplatin-ineligible advanced urothelial cancer.
(FUTURE MEDICINE LTD, 2020-09-16)
The choice of first-line therapy for patients with metastatic urothelial cancer (mUC) is based on cisplatin-eligibility and programmed death-ligand 1 (PD-L1) status. For patients with mUC who are ineligible for cisplatin ...