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Targeting aneuploidy, CIN and mechanisms of DNA content reduction in cancer
(Institute of Cancer Research (University Of London), 2021-02-28)
Chromosomal instability (CIN) and aneuploidy are distinct events that can coexist in a tumour and one can result from the other. They can arise through direct errors in mitosis or in DNA damage repair and response machineries, ...
Markers predictive of response, resistance and relapse in colorectal cancer
(Institute of Cancer Research (University Of London), 2021-05-31)
Response to neo-adjuvant chemo-radiotherapy (CRT) in locally advanced rectal cancer varies. Circulating tumour DNA (ctDNA) has emerged as a surrogate marker of the tumour genome. I hypothesised that ctDNA could be an early ...
Assessment of Patients' Ability to Review Electronic Health Record Information to Identify Potential Errors: Cross-sectional Web-Based Survey.
(2021-02-26)
Background Sharing personal health information positively impacts quality of care across several domains, and particularly, safety and patient-centeredness. Patients may identify and flag up inconsistencies in their ...
Gustatory function following radiotherapy to the head and neck
(Institute of Cancer Research (University Of London), 2021-11-30)
An intact sense of taste provides pleasure, supports sustenance and alerts the body to potential toxins. Patients with head and neck (HNC) who undergo radiotherapy (RT) are at high risk of developing acute and late taste ...
A commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component
(2021-01-13)
Condensin complexes compact and disentangle chromosomes in preparation for cell division. Commercially available antibodies raised against condensin subunits have been widely used to characterise their cellular interactome. ...
Analyses of PD-L1 and Inflammatory Gene Expression Association with Efficacy of Nivolumab ± Ipilimumab in Gastric Cancer/Gastroesophageal Junction Cancer.
(2021-03-29)
Purpose In advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC), there is a need to identify biomarkers of response to therapies, such as immune checkpoint inhibitors.Patients and methods In post hoc exploratory ...
Computational science-enabled radiological pathology for the non-invasive mapping of tumour heterogeneity in childhood neuroblastoma
(Institute of Cancer Research (University Of London), 2021-01-31)
Neuroblastoma is a common childhood solid tumour that accounts for 15% of all cancer paediatric deaths. This thesis addresses key deficiencies in our ability to define, monitor and predict neuroblastoma heterogeneity for ...
Genetics of high risk myeloma
(Institute of Cancer Research (University Of London), 2021-03-31)
Despite significant progress in therapy in the last two decades, the outlook for multiple myeloma (MM) patients is still poor as the disease remains incurable and only 33% of patients survive for up to 10 years after ...
MicroRNAs as biomarkers of response to HER2 inhibitors in gastro-oesophageal cancers
(Institute of Cancer Research (University Of London), 2021-01-31)
Trastuzumab in combination with chemotherapy represents the standard of care in HER2-positive advanced gastro-oesophageal cancer (GOC), but development of resistance limits response. MicroRNAs (miRs) modulate key pathways ...
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype.
(2021-06-18)
Purpose Much of the heredity of melanoma remains unexplained. We sought predisposing germline copy-number variants using a rare disease approach.Methods Whole-genome copy-number findings in patients with melanoma predisposition ...