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Now showing items 4271-4280 of 4393
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
(Elsevier BV, 2024-05-15)
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD). Although the catalytic function of RIPK1 ...
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
(AMER CHEMICAL SOC, 2023-08-10)
High hit rates from initial ligand-observed NMR screening can make it challenging to prioritize which hits to follow up, especially in cases where there are no available crystal structures of these hits bound to the target ...
Genetic landscape of interval and screen detected breast cancer.
(NATURE PORTFOLIO, 2024-05-28)
Interval breast cancers (IBCs) are cancers diagnosed between screening episodes. Understanding the biological differences between IBCs and screen-detected breast-cancers (SDBCs) has the potential to improve mammographic ...
A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer.
(Massachusetts Medical Society, 2022-09-27)
BACKGROUND: Recurrence of non–muscle-invasive bladder cancer (NMIBC) is common after transurethral resection of bladder tumor (TURBT). Photodynamic diagnosis (PDD) provides better diagnostic accuracy and more complete tumor ...
A comparison between cobalt and linear accelerator-based treatment plans for conformal and intensity-modulated radiotherapy
(BRITISH INST RADIOLOGY, 2008-04)
The simplicity of cobalt units gives them the advantage ofreduced maintenance, running costs and downtime when compared with linear accelerators. However, treatments carried out on such units are typically limited to simple ...
Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital
(Wiley, 2003-01-01)
<jats:p><jats:italic>Purpose:</jats:italic> The aim of this study was to assess treatment and outcome with respect to clinical and pathological features.</jats:p><jats:p><jats:italic>Patients and methods:</jats:italic> ...
Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.
(ELSEVIER, 2024-01-19)
BACKGROUND: Resistance to therapies that target homologous recombination deficiency (HRD) in breast cancer limits their overall effectiveness. Multiple, preclinically validated, mechanisms of resistance have been proposed, ...
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
(Elsevier BV, 2024-05-26)
INTRODUCTION: There is a need to improve the outcomes of patients with head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC), especially in recurrent unresectable and metastatic (R/M) setting. ...
A comprehensive examination of mental health in patients with head and neck cancer: systematic review and meta-analysis.
(OXFORD UNIV PRESS, 2024-04-30)
BACKGROUND: Patients with head and neck cancer present particularly considerable levels of emotional distress. However, the actual rates of clinically relevant mental health symptoms and disorders among this population ...
Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
(ELSEVIER IRELAND LTD, 2024-04-07)
BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus ...