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Now showing items 4271-4280 of 4397
Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital
(Wiley, 2003-01-01)
<jats:p><jats:italic>Purpose:</jats:italic> The aim of this study was to assess treatment and outcome with respect to clinical and pathological features.</jats:p><jats:p><jats:italic>Patients and methods:</jats:italic> ...
Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.
(ELSEVIER, 2024-01-19)
BACKGROUND: Resistance to therapies that target homologous recombination deficiency (HRD) in breast cancer limits their overall effectiveness. Multiple, preclinically validated, mechanisms of resistance have been proposed, ...
A comprehensive examination of mental health in patients with head and neck cancer: systematic review and meta-analysis.
(OXFORD UNIV PRESS, 2024-04-30)
BACKGROUND: Patients with head and neck cancer present particularly considerable levels of emotional distress. However, the actual rates of clinically relevant mental health symptoms and disorders among this population ...
Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
(ELSEVIER IRELAND LTD, 2024-04-07)
BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus ...
Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in BRCA1 and/or BRCA2 in the PROfound Trial.
(LIPPINCOTT WILLIAMS & WILKINS, 2024-02-10)
Olaparib improved PFS and OS across subgroups of BRCA1/2mut #prostatecancer patients in the PROFOUND phase III trial.
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking.
(NATURE PORTFOLIO, 2020-03-27)
Circulating tumour DNA (ctDNA) allows tracking of the evolution of human cancers at high resolution, overcoming many limitations of tissue biopsies. However, exploiting ctDNA to determine how a patient's cancer is evolving ...
Immune reconstitution in children following chemotherapy for acute leukemia.
(WILEY, 2020-07-01)
Although survival rates for pediatric acute lymphoblastic leukemia are now excellent, this is at the expense of prolonged chemotherapy regimens. We report the long-term immune effects in children treated according to the ...
Molecular subtypes of leiomyosarcoma: Moving toward a consensus
(WILEY, 2022-12-01)
Intratumoral therapies in head and neck squamous cell carcinoma: A systematic review and future perspectives.
(ELSEVIER SCI LTD, 2024-06-01)
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) presents an ideal scenario for intratumoral therapies (IT), due to its local recurrence pattern and frequent superficial extension. IT therapies aim to effect tumor ...