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Genetics of high risk myeloma
(Institute of Cancer Research (University Of London), 2021-03-31)
Despite significant progress in therapy in the last two decades, the outlook for multiple myeloma (MM) patients is still poor as the disease remains incurable and only 33% of patients survive for up to 10 years after ...
MicroRNAs as biomarkers of response to HER2 inhibitors in gastro-oesophageal cancers
(Institute of Cancer Research (University Of London), 2021-01-31)
Trastuzumab in combination with chemotherapy represents the standard of care in HER2-positive advanced gastro-oesophageal cancer (GOC), but development of resistance limits response. MicroRNAs (miRs) modulate key pathways ...
Targeting androgen receptor splicing in lethal prostate cancer
(Institute of Cancer Research (University Of London), 2021-04-30)
Over the past decade, androgen receptor (AR) directed therapies such as abiraterone and enzalutamide have become the standard of care for treating advanced prostate cancer, improving both progression-free and overall ...
Roles of cancer associated fibroblasts in squamous cell carcinoma
(Institute of Cancer Research (University Of London), 2021-03-31)
Cancer associated fibroblasts (CAFs) play a key role in the tumour microenvironment (TME) of squamous cell carcinoma. Influenced by cues from cancer cells, CAFS remodel the extracellular matrix and secrete cytokines and ...
Molecular characterisation and functional assessment of FGFR3 mutations in cancer
(Institute of Cancer Research (University Of London), 2020-01-31)
Genetic alterations such as mutations in the Fibroblast Growth Factor Receptors (FGFRs) family play important roles in the development and progression of several cancer types. How these mutations affect protein function ...
Quantitative assessment of patient suitability for magnetic resonance-guided High Intensity Focused Ultrasound Therapy
(Institute of Cancer Research (University Of London), 2021-01-31)
Clinical assessment of a patient's suitability for magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) therapy currently involves subjective judgements based on available diagnostic images and prior ...
Assessment of delivered rectal dose in prostate cancer radiotherapy
(Institute of Cancer Research (University Of London), 2021-11-30)
Prostate radiotherapy gives excellent long-term disease control; however, morbidity from treatment can negatively impact quality of life. To minimise the risk of toxicity a treatment plan is created, which meets dose volume ...
Improvements in molecular diagnostics and image analysis for detecting and managing cervical cancer
(Institute of Cancer Research (University Of London), 2020-12-31)
This thesis addresses improvements in molecular diagnostics and in image analysis, and their combination for managing cervical cancer. Screening cytology has transformed early diagnosis but is resource intensive and highly ...
The molecular characterisation of MET addiction in lung cancer
(Institute of Cancer Research (University Of London), 2020-08-31)
The traditional classification of lung cancer has been radically altered with increased understanding of the molecular alterations and genomic biomarkers that drive the development of the disease. Whilst molecularly targeted ...
Evaluation of dysphagia-optimising radiotherapy techniques in locally advanced oropharyngeal cancer
(Institute of Cancer Research (University Of London), 2020-01-31)
Radiation-associated dysphagia (RAD) following chemoradiation in locally advanced oropharyngeal cancers (LA-OPC) can have a devastating impact on patients' quality of life (QoL). Establishing efficient swallow-sparing ...