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Now showing items 21-30 of 142
Development of methods to assess the predictive power of pre-therapy imaging for selective internal radiation therapy
(Institute of Cancer Research (University Of London), 2020-12-31)
Pre-therapy Technetium-99m (99mTc)-MAA SPECT may be used to predict the 90Y absorbed dose in selective internal radiation therapy (SIRT), while post-therapy 90Y bremsstrahlung SPECT may be used to measure the delivered ...
Measuring tumour evolution at the genetic and epigenetic level in individual patients from cancer genomic data
(Institute of Cancer Research (University Of London), 2020-01-31)
High-throughput genomic data from cancers uncovered high intra and inter-tumour heterogeneity and subclonal architecture of cancer cell populations. If we consider cells as asexually reproducing individuals, we can apply ...
The use of germline genetic profiles to guide prostate cancer targeted screening and cancer care
(Institute of Cancer Research (University Of London), 2020-09-30)
The genetic heritability of prostate cancer is contributed to by rarely occurring but high penetrant genetic variants, and moderate to commonly occurring variants conferring lower risks. Genome wide association studies and ...
The use of three-dimensional surface imaging and assessment of aesthetics in breast cancer surgery
(Institute of Cancer Research (University Of London), 2020-12-31)
Aesthetic outcome from breast cancer surgery influences long-term psychosocial wellbeing. There is no gold standard measure. An objective measure is required in order to communicate and compare results ultimately to raise ...
How RhoGEFs drive triple negative breast cancer cell invasion through the activation of YAP and TAZ
(Institute of Cancer Research (University Of London), 2020-03-31)
Dynamical remodelling of the cytoskeleton is essential for triple negative breast cancer metastasis (TNBC). Cell shape is regulated by RhoGEFs which activate Rho GTPases resulting in changes in actin polymerisation, ...
Investigating the role of DTX3L in the replication stress response
(Institute of Cancer Research (University Of London), 2023-01-20)
DNA replication must be carried out with high fidelity to ensure accurate transfer of genetic information upon cell division. The mechanisms by which damage upon DNA is repaired are extensive and are increasingly well ...
Exploiting the CRL4-CRBM E3 ubiquitin ligase complex for the development of iTAG: a versatile targeted protein degradation system to enable functional evaluation and target validation
(Institute of Cancer Research (University Of London), 2022-02-28)
Modulating target protein expression to probe for its relevance and function in a disease is critical in the drug discovery process of target validation. Current genetic methods and chemico-biology tools are widely employed ...
PET imaging to monitor NET-1 and GD2 expression in neuroblastoma
(Institute of Cancer Research (University Of London), 2021-01-31)
Within neuroblastoma (NB), approximately 50% of patients are considered high-risk, presenting widespread distant metastasis and, frequently, MYCN amplification. NB is further characterised by the selective presence of the ...
Investigating the mehcanisms of drug resistance in gastro-intestinal cancers
(Institute of Cancer Research (University Of London), 2020-03-31)
Despite many effective therapies for gastro-intestinal (GI) cancers, both primary and acquired mechanisms of resistance commonly occur. The subclonal complexity of intra-tumoural heterogeneity in these cancers further ...
Functional characterisation of EGFR mutations in cancer
(Institute of Cancer Research (University Of London), 2021-08-31)
Large-scale pan-cancer sequencing of tumour samples has identified a plethora of epidermal growth factor (EGFR) mutations along the full length of the gene. However, clinical studies have demonstrated that distinct mutations ...