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Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study
(NATURE PUBLISHING GROUP, 2009-03-17)
Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a ...
Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study
(NATURE PUBLISHING GROUP, 2009-03-31)
We obtained lifetime occupational and residential histories by telephone interview with 622 mesothelioma patients (512 men, 110 women) and 1420 population controls. Odds ratios (ORs) were converted to lifetime risk (LR) ...
Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis
(BIOMED CENTRAL LTD, 2009-08)
Background: The availability of the complete chicken (Gallus gallus) genome sequence as well as a large number of chicken probes for fluorescent in-situ hybridization (FISH) and microarray resources facilitate comparative ...
Functional characterization of E- and P-cadherin in invasive breast cancer cells
(BIOMED CENTRAL LTD, 2009-03-03)
Background: Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is ...
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology
(2009)
Background: In recent years RNAi screening has proven a powerful tool for dissecting gene functions in animal cells in culture. However, to date, most RNAi screens have been performed in a single cell line, and results ...
Concepts of epigenetics in prostate cancer development
(NATURE PUBLISHING GROUP, 2009-01-22)
Substantial evidence now supports the view that epigenetic changes have a role in the development of human prostate cancer. Analyses of the patterns of epigenetic alteration are providing important insights into the origin ...
Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim
(PUBLIC LIBRARY SCIENCE, 2009-06)
In human B cells infected with Epstein-Barr virus (EBV), latency-associated virus gene products inhibit expression of the proapoptotic Bcl-2-family member Bim and enhance cell survival. This involves the activities of the ...
Multigene expression of protein complexes by iterative modification of genomic Bacmid DNA
(BIOMED CENTRAL LTD, 2009-09-02)
Background: Many cellular multi-protein complexes are naturally present in cells at low abundance. Baculovirus expression offers one approach to produce milligram quantities of correctly folded and processed eukaryotic ...
Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
(PUBLIC LIBRARY SCIENCE, 2009-01)
The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes. We have determined the impact of Lkb1 deficiency on intestinal homeostasis, particularly focussing on secretory cell ...