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Dynamic predictive joint models to characterise localised prostate cancer prognosis after radiotherapy
(Institute of Cancer Research (University Of London), 2023-09-19)
This thesis aims to develop and validate dynamic predictive joint models (JMs) to characterise the prognosis of patients with localised prostate cancer who are treated with moderately hypofractionated radiotherapy with ...
Identifying predictive and prognostic markers in localised oesophagogastric cancer
(Institute of Cancer Research (University Of London), 2022-11-23)
The survival of patients with localised oesophagogastric (OG) cancer is poor even with multimodality therapy and modern surgical techniques. The need to identify robust but easily-reproducible prognostic and predictive ...
Exploring tumour evolution through single-cell sequencing
(Institute of Cancer Research (University Of London), 2023-10-24)
Tumours are composed of heterogeneous populations of cells which, under the pressure of the host and
external treatments, evolve across time and space. Recent advances in next-generation sequencing
technologies have ...
Targeting therapeutic vulnerabilities associated with EWS fusion proteins in Ewing sarcoma
(Institute of Cancer Research (University Of London), 2021-01-31)
Ewing sarcoma (ES) is a are and aggressive bone tumour affecting children and young adults and that requires better therapeutic options to improve patient outcomes. ES is characterised by chromosomal rearrangements producing ...
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
(Institute of Cancer Research (University Of London), 2023-10-10)
The PSMC3IP MND1 heterodimer promotes RAD51 and DMC1-dependent D loop formation during meiosis in yeast and mammalian organisms. For this purpose, it catalyses the DNA strand exchange activities of the recombinases. ...
A biochemical analysis of human shelterin complexes
(Institute of Cancer Research (University Of London), 2022-08-25)
Linear chromosomes present two major challenges, known as the end-replication and end-protection problems. The human shelterin complex is a dynamic assembly of six components, consisting of TRF1, TRF2, RAP1, TIN2, TPP1, ...
Design and synthesis of bifunctional molecules for directing phosphorylation
(Institute of Cancer Research (University Of London), 2023-05-04)
The field of bifunctional molecules such as PROTAC, DUBTAC and PhoRC has demonstrated that inducing proximity between two protein complexes is sufficient to redirect post-translational modifications (PTMs), and effect ...
Improving the multiple myeloma patient pathway: microsampling for remote monitoring of free light chains
(Institute of Cancer Research (University Of London), 2023-01-24)
Multiple myeloma (MM) is categorised as a relapsing-remitting blood cancer with unpredictable relapse patterns. Due to an inevitable relapse, blood test monitoring is crucial and requires frequent visits to the phlebotomy ...
Metabolic phenotyping using the iKnife identifies IRS2 as a driver of lipid metabolism reprogramming in colorectal cancer
(Institute of Cancer Research (University Of London), 2022-11-22)
The advent of precision medicine is changing the clinicians' approach to therapeutic decisions. It also implies that the identification of biomarkers and discriminating factors is necessary for more effective treatment ...
Targeting DNA damage response in oesophagogastric cancers
(Institute of Cancer Research (University Of London), 2023-05-30)
A subset of patients with oesphophagogastric (OG) adenocarcinomas are characterised by homologous recombination repair deficiency (HRD), providing the rationale for poly (ADP-ribose) polymerase inhibitor (PARPi) therapy ...