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Utilising novel therapies in the treatment of gastrointestinal cancers
(Institute of Cancer Research (University Of London), 2023-05-04)
Background:
Gastrointestinal (GI) malignancies are common and frequently lethal diseases. For most, treatment options revolve around chemotherapy where efficacy beyond second line is negligible, and toxicity is high. Novel ...
Identification of autophagy-specific cargo and characterization of b-catenin as LC3/GABARAP interacting protein
(Institute of Cancer Research (University Of London), 2023-07-17)
Autophagy is an evolutionary conserved eukaryotic degradation system induced under cellular stress conditions in which cellular components, such as damaged organelles, and aggregated proteins sequestrated through lysomal ...
Investigating determinants of sensitivity and resistance to T cell redirecting antibodies in colorectal cancer through patient derived organoid models
(Institute of Cancer Research (University Of London), 2023-06-12)
Most colorectal cancers (CRCs) do not respond to treatment with immune-checkpoint-inhibitors due to modest mutation loads, low cytotoxic T cell infiltrates, and immunosuppressive microenvironments. The CEA-TCB bispecific ...
Incorporating germline genetics into personalised risk-assessment in the detection of prostate cancer in men with an elevated genetic risk
(Institute of Cancer Research (University Of London), 2022-11-23)
Hypothesis - Prostate biopsy outcomes for men with a genetic predisposition to prostate cancer (PrCa) can be predicted from germline genetic profiling and clinical factors.
Prostate cancer (PrCa) is the second most common ...
Molecular profiling of cell free DNA in patients with paediatric solid tumours
(Institute of Cancer Research (University Of London), 2023-05-02)
Tumour tissue profiling studies show that a substantial proportion of paediatric cancer patients have potentially actionable alterations and minimally invasive molecular profiling test using cell free DNA (cfDNA) could ...
Harnessing the power of cryo electron microscopy to visualise a full-length kinesin KIFC1 (HSET)
(Institute of Cancer Research (University Of London), 2023-05-30)
Cancer cells are known to exhibit a phenomenon typically known as centrosome amplification (CA), which is responsible for multipolar spindle formation during mitosis. This severely impairs cytokinesis and could hence prove ...
Exploiting proteomic mass spectrometry analysis to understand the roles of BAF chromatin remodelling complex subunit ARID1A
(Institute of Cancer Research (University Of London), 2023-06-09)
AT-rich interactive domain-containing protein 1A (ARID1A) is the most frequently mutated subunit of BRG/Brahma-associated factors (BAF) chromatin remodelling complex across diverse cancer types. Although some roles of BAF ...
Mapping the dynamic immune landscape associated with therapeutic response in soft tissue sarcoma
(Institute of Cancer Research (University Of London), 2023-10-24)
Soft tissue sarcomas (STS) are a group of rare and heterogenous cancers of unmet need. In the advanced setting, and following failure of first-line anthracycline therapy, further line therapeutic options offer limited ...
Generating patient-derived models of soft-tissue sarcoma for the evaluation of therapy response and resistance
(Institute of Cancer Research (University Of London), 2023-05-04)
For the majority of patients, advanced soft-tissue sarcoma (STS) is fatal, with an overall survival of 14-19 months. Systemic chemotherapy has remained the cornerstone of advanced STS control for more than 30 years and ...
Spatial interrogation of tumour microenvironment using artificial intelligence
(Institute of Cancer Research (University Of London), 2023-03-06)
The tumour microenvironment can provide critical information for disease diagnosis, treatment planning, and prognosis. However, the complexity of its morphological, cellular, and spatial architecture hinders accurate ...