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Now showing items 161-169 of 169
Reconstructing cancer evolution at the single-cell level in patient-derived organoids
(Institute of Cancer Research (University Of London), 2024-01-30)
Genetic mutations in cancer driver genes are heritable and can confer aggressive and therapy-resistant properties to cells. However genetic driver events do not fully explain the malignant phenotype, and it is becoming ...
Stereotactic radiosurgery for brain metastases: efficacy and toxicity
(Institute of Cancer Research (University Of London), 2024-02-05)
Stereotactic radiosurgery (SRS) is increasingly being used as a treatment for brain metastases. Four research topics in the management of brain metastases in clinical practice have been chosen, with the unifying theme of ...
Capture Hi-C to identify regulatory variants and target genes influencing breast cancer risk
(Institute of Cancer Research (University Of London), 2022-10-26)
Genome wide association studies have discovered approximately 200 breast cancer risk single nucleotide polymorphisms, most of which map to non-protein-coding regions. To understand the mechanisms influencing disease risk, ...
Systemic biomarkers of immune response in locally-advanced human papillomavirus malignancies treated with radical chemoradiation
(Institute of Cancer Research (University Of London), 2024-02-19)
Human papillomavirus (HPV)-driven malignancies exhibit viral oncogenic proteins that act as tumour-specific antigens, making them suitable candidates for monitoring the adaptive immune response during treatment. Chemoradiation ...
Spatial Phenotyping of Tumour Immune Microenvironment in the Non-small Cell Lung Cancer Using Artificial Intelligence
(Institute of Cancer Research (University Of London), 2024-02-26)
Lung cancer is the second most common cancer type worldwide, with a five-year survival rate of about 20%. The aggressiveness of the disease and the inefficiency of treatment are partially attributed to the intra-tumour ...
Molecular subtypes of cancer-associated fibroblasts and their regulation of the tumour microenvironment in pancreatic ductal adenocarcinoma.
(Institute of Cancer Research (University Of London), 2024-03-21)
Pancreatic Ductal Adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths, with a 5-year survival rate of less than 10 % in Western countries. Transcriptomic analysis of PDAC in the last decade has unearthed ...
On the Co-Dependence of Cell Morphology and Biochemistry in Cancer
(Institute of Cancer Research (University Of London), 2024-03-25)
Shape and form are fundamental to biology. Acting at all scales, from the organismal to the molecular, morphology defines the functionality of biological structures. It is obvious that chemical events in the cell, influence ...
Targeting Endo180 with an antibody-drug conjugate for cancer treatment
(Institute of Cancer Research (University Of London), 2024-03-22)
Antibody-drug conjugates (ADCs) are formed of an antibody attached to a cytotoxic drug via a linker which is cleaved upon internalisation of the ADC into the cell. This allows very toxic drugs to be directed to specific ...
Development of Real-Time Motion-Including Dose Reconstruction on a Unity MR-Linac system
(Institute of Cancer Research (University Of London), 2024-03-12)
The first part of my thesis is concerned with estimating the motion of organs and other critical anatomical structures during radiotherapy treatments. I use 2D cine images acquired during MR-Linac treatments and compare ...