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Molecular subtypes of cancer-associated fibroblasts and their regulation of the tumour microenvironment in pancreatic ductal adenocarcinoma.
(Institute of Cancer Research (University Of London), 2024-03-21)
Pancreatic Ductal Adenocarcinoma (PDAC) remains a leading cause of cancer-related deaths, with a 5-year survival rate of less than 10 % in Western countries. Transcriptomic analysis of PDAC in the last decade has unearthed ...
On the Co-Dependence of Cell Morphology and Biochemistry in Cancer
(Institute of Cancer Research (University Of London), 2024-03-25)
Shape and form are fundamental to biology. Acting at all scales, from the organismal to the molecular, morphology defines the functionality of biological structures. It is obvious that chemical events in the cell, influence ...
Development of Real-Time Motion-Including Dose Reconstruction on a Unity MR-Linac system
(Institute of Cancer Research (University Of London), 2024-03-12)
The first part of my thesis is concerned with estimating the motion of organs and other critical anatomical structures during radiotherapy treatments. I use 2D cine images acquired during MR-Linac treatments and compare ...
Advancing magnetic resonance imaging (MRI) guided adaptive radiotherapy techniques for prostate cancer
(Institute of Cancer Research (University Of London), 2024-04-11)
Advances in radiotherapy technology have increased precision of treatment delivery, improved cure rates and decreased side effects. The advent of MR-Linacs, which are hybrids of an MRI scanner and linear accelerator, holds ...
Prediction of lymph node metastases using immunohistochemical analysis of primary oral tongue squamous cell carcinomas
(Institute of Cancer Research (University Of London), 2024-04-19)
We studied archival tissue samples of oral tongue squamous cell carcinoma (OTSCC) for the expression of genes that have been identified, by cDNA microarray studies and previous studies, to be highly discriminatory for lymph ...
Preclinical Modelling of Adenoid Cystic Carcinoma
(Institute of Cancer Research (University Of London), 2024-05-03)
Adenoid cystic carcinoma (ACC) lacks accurate preclinical models. Those models that do exist often fail to recapitulate the biology of the disease, lacking expression of the key genetic aberration found in ACC, a MYB::NFIB ...
Herding clonal evolution to overcome drug resistance in high-grade serous ovarian cancer
(Institute of Cancer Research (University Of London), 2024-06-04)
Ovarian cancer (OC) is one of the most common malignancies responsible for cancer-related deaths in women, and finding new treatment strategies is an area of unmet clinical need. To investigate how the concepts of cancer ...
Targeting the tumour microenvironment with endosialin-directed CAR T-cells
(Institute of Cancer Research (University Of London), 2022-05-31)
Advances in T-cell engineering have facilitated the generation of CAR T-cells that successfully deplete malignant cells of haematological cancers. However, attempts to target solid tumours with CAR T-cells have been hindered ...
Targeting the inflammatory response in advanced prostate cancer
(Institute of Cancer Research (University Of London), 2024-05-20)
Prostate cancer is a leading cause of male cancer mortality. Despite inflammation being implicated in prostate cancer initiation and progression, patient outcomes have been minimally impacted by immunotherapies that have ...
Systems biology of the motif-mediated cell cycle interactome
(Institute of Cancer Research (University Of London), 2024-05-09)
The eukaryotic cell cycle is a tightly controlled series of events leading to cell division. It relies on a complex network of regulatory proteins, serving as checkpoints to oversee DNA replication and ensure orderly cell ...