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Now showing items 11-20 of 29
Monitoring tumour response to extracellular matrix modulation with multiparametric MRI
(Institute of Cancer Research (University Of London), 2022-04-30)
Primary breast tumours are characterised by a dense extracellular matrix (ECM), with accumulation of collagen and hyaluronan (HA). This stromal dense phenotype is associated with tumour progression, metastasis and poor ...
Characterisation of RELA dynamics in pancreatic ductal adenocarcinoma
(Institute of Cancer Research (University Of London), 2022-07-06)
The NF-kB transcription factor RELA is a master regulator of the immune response and cell survival. Numerous studies have determined the parameters and configuration of single cell RELA translocation dynamics, with various ...
Mathematical modelling of subclonal interactions in paediatric high-grade gliomas
(Institute of Cancer Research (University Of London), 2022-05-31)
Despite a low overall mutational burden, paediatric high-grade gliomas (pHGG) display high intra-tumour heterogeneity. Accumulating evidence suggest the presence of cellular mechanisms that maintain such high heterogeneity, ...
Local therapeutic approaches for the management of recurrent gynaecological cancer
(Institute of Cancer Research (University Of London), 2022-02-28)
Surgery, radiotherapy and chemotherapy combinations are used to treat recurrent gynaecological malignancy. Stereotactic body radiotherapy (SBRT) delivered to the involved surgical margin could improve clinical outcomes ...
Development of novel therapeutic strategies in relapsed advanced/metastatic non-small cell lung cancer
(Institute of Cancer Research (University Of London), 2022-02-28)
Recent advances in the treatment of advanced NSCLC include introduction of targeted therapies and immune-checkpoint inhibitors, leading to improvements in survival outcomes. However, significant new challenges and questions ...
Magnetic resonance guided radiotherapy for the treatment of bladder and pancreatic cancer
(Institute of Cancer Research (University Of London), 2022-08-05)
Magnetic resonance guided radiotherapy (MRgRT) has many postulated benefits over conventional radiotherapy treatment techniques. Its superior soft tissue definition, lack of imaging related ionising radiation and the ...
Genetics of relapse and treatment resistance in multiple myeloma
(Institute of Cancer Research (University Of London), 2022-05-31)
Better understanding of the mechanisms of relapse and treatment resistance in myeloma could improve clinical outcomes. Copy number aberrations (CNA) are a major feature of multiple myeloma, however their evolution over ...
Breast cancer and common malignancies in older adults
(Institute of Cancer Research (University Of London), 2022-08-08)
Cancer is increasingly a diseases of older adults. However, they are heterogeneous and life expectancy and tolerance to stressors may vary greatly within this age group. Comorbidities, functional impairments, malnutrition, ...
An in vivo investigation of dynamic contrast-enhanced ultrasound (DCE-US) imaging for the assessment of tumour response to radiotherapy
(Institute of Cancer Research (University Of London), 2022-08-22)
Imaging biomarkers of early response to cancer therapy can facilitate more effective treatment adaptation and improve cancer management. These biomarkers can detect functional, structural or molecular tumour changes that ...
Structural investigation of NTC and of the coupling between splicing and polyadenylation
(Institute of Cancer Research (University Of London), 2022-10-31)
This PhD thesis is composed of two parts. The first and foremost part describes the reconstitution, isolation and analysis of human complexes involved in the coupling between splicing and polyadenylation, with a special ...