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Identifying predictive and prognostic markers in localised oesophagogastric cancer
(Institute of Cancer Research (University Of London), 2022-11-23)
The survival of patients with localised oesophagogastric (OG) cancer is poor even with multimodality therapy and modern surgical techniques. The need to identify robust but easily-reproducible prognostic and predictive ...
A biochemical analysis of human shelterin complexes
(Institute of Cancer Research (University Of London), 2022-08-25)
Linear chromosomes present two major challenges, known as the end-replication and end-protection problems. The human shelterin complex is a dynamic assembly of six components, consisting of TRF1, TRF2, RAP1, TIN2, TPP1, ...
Metabolic phenotyping using the iKnife identifies IRS2 as a driver of lipid metabolism reprogramming in colorectal cancer
(Institute of Cancer Research (University Of London), 2022-11-22)
The advent of precision medicine is changing the clinicians' approach to therapeutic decisions. It also implies that the identification of biomarkers and discriminating factors is necessary for more effective treatment ...
Investigation of the effects of hydrogen peroxide in combination with ionising radiation in cancer
(Institute of Cancer Research (University Of London), 2022-10-18)
Introduction
In the early 2000s, Japanese colleagues reported sensitisation of normal and tumour cell lines to cytotoxic doses of ionising radiation (IR) by low concentrations of hydrogen peroxide (H2O2), research that ...
Discovery of NEK9 and Aurora A PROTACs using a proteomics-based screening approach
(Institute of Cancer Research (University Of London), 2022-12-12)
Chemically induced degradation has emerged as a valuable tool in chemical biology and medicinal chemistry for both potential therapies, and to investigate protein function. Proteolysis targeting chimeras (PROTACs) are small ...
Investigation of combination treatments using radiotherapy and stimulators of nucleic-acid sensing immune pathways in an organoid model of basal-like breast cancer
(Institute of Cancer Research (University Of London), 2022-10-12)
The majority of triple-negative breast cancers (TNBC) are of the basal-like subtype, which has a poorer prognosis than non-basal TNBC. Few targeted therapies are approved for TNBC, and although immune checkpoint inhibitors ...
Incorporating germline genetics into personalised risk-assessment in the detection of prostate cancer in men with an elevated genetic risk
(Institute of Cancer Research (University Of London), 2022-11-23)
Hypothesis - Prostate biopsy outcomes for men with a genetic predisposition to prostate cancer (PrCa) can be predicted from germline genetic profiling and clinical factors.
Prostate cancer (PrCa) is the second most common ...
Circulating tumour DNA analysis in advanced breast cancer
(Institute of Cancer Research (University Of London), 2022-10-17)
Circulating tumour DNA (ctDNA) analysis shows great potential both as an approach to understand the evolution of advanced breast cancer (ABC) and as a clinical tool to assist in ABC management. ctDNA analysis has not yet ...
Capture Hi-C to identify regulatory variants and target genes influencing breast cancer risk
(Institute of Cancer Research (University Of London), 2022-10-26)
Genome wide association studies have discovered approximately 200 breast cancer risk single nucleotide polymorphisms, most of which map to non-protein-coding regions. To understand the mechanisms influencing disease risk, ...