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Functional characterisation of EGFR mutations in cancer
(Institute of Cancer Research (University Of London), 2021-08-31)
Large-scale pan-cancer sequencing of tumour samples has identified a plethora of epidermal growth factor (EGFR) mutations along the full length of the gene. However, clinical studies have demonstrated that distinct mutations ...
Applications of intertumoural, intratumoural and intermolecular heterogeneity for personalised medicine in colorectal cancer
(Institute of Cancer Research (University Of London), 2020-03-31)
Colorectal cancer (CRC) is a heterogeneous disease, both at the molecular level and in the context of patients' responses to treatment. Few biomarkers are currently in place that can help to stratify patients in the clinical ...
Developing biomarker guided treatments for colorectal cancer
(Institute of Cancer Research (University Of London), 2021-09-30)
Magnetic resonance imaging (MRI) guided radiotherapy for prostate cancer
(Institute of Cancer Research (University Of London), 2020-11-30)
Radiotherapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. Magnetic resonance imaging (MRI) guided radiotherapy allows daily adaptive replanning and can improve ...
Circulating cell-free DNA methylation analysis of metastatic prostate cancer
(Institute of Cancer Research (University Of London), 2020-03-31)
Introduction; Materials and methods; Deciphering global plasma DNA methylation variance in metastatic prostate cancer; Implementation of a methylation signature for tracking and detection of prostate cancer in plasma; ...
Molecular mechanisms of PARP inhibitor sensitivity in primary triple negative breast cancer
(Institute of Cancer Research (University Of London), 2021-08-31)
Triple negative breast cancer (TNBC) encompasses molecularly different subgroups, with a subgroup harbouring evidence of defective homologous recombination (HR) DNA repair. At present there are no biomarkers available in ...
Circulating tumour DNA in advanced thyroid cancer
(Institute of Cancer Research (University Of London), 2021-02-28)
Conventional biomarkers currently used in thyroid cancer are not disease specific and fluctuate in advanced disease, making interpretation difficult. Circulating tumour DNA (ctDNA) has been shown to be a useful in other ...
Revealing mechanisms of metabolic pathways associated with cancer pain
(Institute of Cancer Research (University Of London), 2021-06-30)
Dysregulation of lipid metabolism is a hallmark of oncogenesis. Many lipid metabolites have been implicated in non-cancer pain states, but their role in cancer-related pain has yet to be firmly established. Previous work ...
Tracking the molecular and metabolic fingerprints of inhalational versus intravenous anaesthetics in preclinical models of breast cancer
(Institute of Cancer Research (University Of London), 2021-09-30)
Fragment-based discovery of HSP70 inhibitors
(Institute of Cancer Research (University Of London), 2021-01-31)
Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and are often associated with metastasis and poor prognosis. Dual silencing of two isoforms, HSP72 and HSC70, using siRNA ...