A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines
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Date
2018-01-17ICR Author
Author
Gill, DM
Iveson, M
Collins, I
Jones, AM
Type
Journal Article
Metadata
Show full item recordAbstract
The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.
Collections
Subject
Science & Technology
Physical Sciences
Chemistry, Organic
Chemistry
Mitsunobu
Cyclodehydration
Nucleophilic aromatic substitution
Intramolecular
Cyclisation
INHIBITORS
CYCLODEHYDRATION
HSP70
PHASE
Research team
Medicinal Chemistry 2
Language
eng
Date accepted
2017-12-04
License start date
2018-01-17
Citation
TETRAHEDRON LETTERS, 2018, 59 (3), pp. 238 - 242 (5)
Publisher
PERGAMON-ELSEVIER SCIENCE LTD