A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines
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The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.
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Medicinal Chemistry 2
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Tetrahedron Letters, 59 pp. 238 - 242